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FKBP1A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS419805

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
FKBP1A, Polyclonal Antibody
Full Product Name
Anti-FKBP1A Antibody
Product Gene Name
anti-FKBP1A antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Specificity
Western blot analysis of extracts of mouse cerebellum tissue, using FKBP1A antibody.
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
11,951 Da
OMIM
M34539 mRNA
Immunogen
Recombinant protein of human FKBP1A
Storage Buffer
PBS with 0.02% sodium azide,50% glycerol, pH7.3.
Applications Tested/Suitable for anti-FKBP1A antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-FKBP1A antibody
WB: 1:500 - 1:2000
IHC: 1:50- 1:200

Western Blot (WB) of anti-FKBP1A antibody

Rabbit Anti-FKBP1A Polyclonal Antibody – Cat# MBS419805

Other Notes

Small volumes of anti-FKBP1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FKBP1A purchase

MBS419805 is an antibody targeting FKBP1A. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP1A. It may not necessarily be applicable to this product.

NCBI GI #
49457332
NCBI GeneID
2280
NCBI Accession #
CAG46965.1
UniProt Secondary Accession #
P20071; Q4VC47; Q6FGD9; Q6LEU3; Q9H103; Q9H566; D3DVW6
UniProt Related Accession #
P62942
NCBI Official Full Name
FKBP1A
NCBI Official Synonym Full Names
FK506 binding protein 1A
NCBI Official Symbol
FKBP1A
NCBI Official Synonym Symbols
FKBP1; PKC12; PKCI2; FKBP12; PPIASE; FKBP-12; FKBP-1A
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase FKBP1A
UniProt Synonym Protein Names
12 kDa FK506-binding protein; 12 kDa FKBP; FKBP-12; Calstabin-1; FK506-binding protein 1A; FKBP-1A; Immunophilin FKBP12; Rotamase
Protein Family
Peptidyl-prolyl cis-trans isomerase
UniProt Gene Name
FKBP1A
UniProt Synonym Gene Names
FKBP1; FKBP12; PPIase FKBP1A; 12 kDa FKBP; FKBP-12; FKBP-1A
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase FKBP1A

UniProt Comments for FKBP1A

FKBP12: an immunophilin and peptidyl-prolyl cis-trans isomerase that binds to the immunosuppressant drugs FK506 (a.k.a. tacrolimus or Fujimycin) and rapamycin (a.k.a. Sirolimus). The FKBP12/rapamycin complex binds NFAT transcription factors and inhibits the induction of T cell genes including IL-2, IL-3, IL-4, TNF-alpha and GM-CSF. FK506 is used in treating patients after organ transplant and those suffering from autoimmune disorders. The immunosuppressant activity of FKBP12 is not apparently related to its prolyl isomerase activity. The FKBP12/rapamycin complex inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding the mTOR Complex1 (mTORC1). mTORC1 contains Raptor, mLST8, and PRAS40, and interacts with DEPTOR, which inhibits its activity. mTOR, a S/T protein kinase, is a central regulator of cellular growth and metabolism. Its inhibition enhances the dependence on aerobic glycolysis in leukemic cells.

Protein type: EC 5.2.1.8; Isomerase

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum membrane; membrane; Z disc

Molecular Function: activin binding; calcium channel inhibitor activity; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; signal transducer activity; SMAD binding; transforming growth factor beta receptor binding

Biological Process: 'de novo' protein folding; fibril organization and biogenesis; heart morphogenesis; negative regulation of protein phosphatase type 2B activity; negative regulation of release of sequestered calcium ion into cytosol; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein binding; positive regulation of protein ubiquitination; protein maturation via protein folding; protein peptidyl-prolyl isomerization; protein refolding; regulation of activin receptor signaling pathway; regulation of immune response; regulation of protein localization; SMAD protein complex assembly; transforming growth factor beta receptor signaling pathway; ventricular cardiac muscle morphogenesis
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Research Articles on FKBP1A

1. Findings indicate that mutant huntingtin (mHTT) aggregates can be transformed into benign species by isomerase FKBP12.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FKBP1A antibody

 Reference Product  PubMed Publications
 MTOR antibody  >5 publications with FKBP1A and MTOR

Pathways associated with anti-FKBP1A antibody

 Products by Pathway  Pathway Diagram
 ALK1 Pathway antibodies  ALK1 Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 ALK2 Signaling Events Pathway antibodies  ALK2 Signaling Events Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
 Role Of Calcineurin-dependent NFAT Signaling In Lymphocytes Pathway antibodies  Role Of Calcineurin-dependent NFAT Signaling In Lymphocytes Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram

Diseases associated with anti-FKBP1A antibody

 Disease Name  Pubmed Publications
 Muscular Diseases Antibodies  >3 publications with FKBP1A and Muscular Diseases
 Cardiovascular Diseases Antibodies  >2 publications with FKBP1A and Cardiovascular Diseases
 Inflammation Antibodies  >2 publications with FKBP1A and Inflammation
 Neoplasms Antibodies  >2 publications with FKBP1A and Neoplasms
 Central Nervous System Diseases Antibodies  >1 publications with FKBP1A and Central Nervous System Diseases
 Lymphoma, T-Cell Antibodies  >1 publications with FKBP1A and Lymphoma, T-Cell
 Growth Disorders Antibodies  >1 publications with FKBP1A and Growth Disorders
 Hypertrophy Antibodies  >1 publications with FKBP1A and Hypertrophy
 Hypertension Antibodies  >1 publications with FKBP1A and Hypertension
 Melanoma Antibodies  >1 publications with FKBP1A and Melanoma

Organs/Tissues associated with anti-FKBP1A antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2 publications with FKBP1A and Bone
 Lung Antibodies  >1 publications with FKBP1A and Lung
 Brain Antibodies  >1 publications with FKBP1A and Brain
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