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GABRA2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS419826

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
GABRA2, Polyclonal Antibody
Full Product Name
Anti-GABRA2 Antibody
Product Gene Name
anti-GABRA2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Specificity
Western blot analysis of extracts of mouse brain, using GABRA2 antibody. Immunohistochemistry of paraffin-embedded rat kidney using GABRA2 antibody at dilution of 1:100 (200x lens). Immunohistochemistry of paraffin-embedded human esophageal cancer using GABRA2 antibody at dilution of 1:100 (400x lens).
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
52,064 Da
OMIM
S62907 mRNA
3D Structure
ModBase 3D Structure for P47869
Immunogen
Recombinant protein of human GABRA2
Storage Buffer
PBS with 0.02% sodium azide,50% glycerol, pH7.3.
Applications Tested/Suitable for anti-GABRA2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-GABRA2 antibody
WB: 1:500 - 1:2000
IHC: 1:50- 1:200

Western Blot (WB) of anti-GABRA2 antibody

Rabbit Anti-GABRA2 Polyclonal Antibody – Cat# MBS419826

Immunohistochemistry (IHC) of anti-GABRA2 antibody

Rabbit Anti-GABRA2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS419826

Immunohistochemistry (IHC) of anti-GABRA2 antibody

Rabbit Anti-GABRA2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS419826

Other Notes

Small volumes of anti-GABRA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GABRA2 purchase

MBS419826 is an antibody targeting GABRA2. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GABRA2. It may not necessarily be applicable to this product.

NCBI GI #
1061214217
NCBI GeneID
2555
NCBI Accession #
NP_001317619.1
UniProt Primary Accession #
P47869
UniProt Secondary Accession #
Q59G14; A8K0U7; B7Z1H8
UniProt Related Accession #
P47869
GenBank Nucleotide #
NM_001330690.1
NCBI Official Full Name
gamma-aminobutyric acid receptor subunit alpha-2 isoform c
NCBI Official Synonym Full Names
gamma-aminobutyric acid type A receptor alpha2 subunit
NCBI Official Symbol
GABRA2
UniProt Protein Name
Gamma-aminobutyric acid receptor subunit alpha-2
UniProt Synonym Protein Names
GABA(A) receptor subunit alpha-2
Protein Family
Gamma-aminobutyric acid receptor
UniProt Gene Name
GABRA2
NCBI Protein Information
gamma-aminobutyric acid receptor subunit alpha-2

NCBI Summary for GABRA2

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
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UniProt Comments for GABRA2

GABRA2: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 4p12

Cellular Component: integral to synaptic vesicle membrane; plasma membrane

Molecular Function: benzodiazepine receptor activity; GABA-A receptor activity; GABA-gated chloride ion channel activity

Biological Process: gamma-aminobutyric acid signaling pathway; neurotransmitter transport; regulation of neurotransmitter levels

Disease: Alcohol Dependence
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Research Articles on GABRA2

1. SNP rs279858 mediates alcohol drinking in alcohol dependent individuals

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GABRA2 antibody

 Reference Product  PubMed Publications
 GABRA4 antibody  >18 publications with GABRA2 and GABRA4
 GABRG2 antibody  >13 publications with GABRA2 and GABRG2
 GABRB1 antibody  >13 publications with GABRA2 and GABRB1
 GABRB2 antibody  >11 publications with GABRA2 and GABRB2
 GABRB3 antibody  >6 publications with GABRA2 and GABRB3
 GABRG3 antibody  >5 publications with GABRA2 and GABRG3
 GPHN antibody  >1 publications with GABRA2 and GPHN

Pathways associated with anti-GABRA2 antibody

 Products by Pathway  Pathway Diagram
 GABA A Receptor Activation Pathway antibodies  GABA A Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-GABRA2 antibody

 Disease Name  Pubmed Publications
 Alcoholism Antibodies  >78 publications with GABRA2 and Alcoholism
 Nervous System Diseases Antibodies  >20 publications with GABRA2 and Nervous System Diseases
 Anxiety Disorders Antibodies  >17 publications with GABRA2 and Anxiety Disorders
 Brain Diseases Antibodies  >12 publications with GABRA2 and Brain Diseases
 Epilepsy Antibodies  >11 publications with GABRA2 and Epilepsy
 Depressive Disorder Antibodies  >8 publications with GABRA2 and Depressive Disorder
 Memory Disorders Antibodies  >7 publications with GABRA2 and Memory Disorders
 Learning Disorders Antibodies  >7 publications with GABRA2 and Learning Disorders
 Cognition Disorders Antibodies  >6 publications with GABRA2 and Cognition Disorders
 Seizures Antibodies  >6 publications with GABRA2 and Seizures

Organs/Tissues associated with anti-GABRA2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >89 publications with GABRA2 and Brain
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