IPO5 Antibody – Rabbit Polyclonal

KPNB3: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Belongs to the importin beta family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Karyopherin; Nuclear import; Nucleolus

Chromosomal Location of Human Ortholog: 13q32.2

Cellular Component: cytoplasm; Golgi apparatus; intracellular membrane-bound organelle; membrane; nuclear membrane; nuclear pore; nucleoplasm; nucleus

Molecular Function: GTPase inhibitor activity; nuclear localization sequence binding; protein binding; protein transporter activity

Biological Process: NLS-bearing substrate import into nucleus; positive regulation of protein import into nucleus; protein import into nucleus, docking; protein import into nucleus, translocation; ribosomal protein import into nucleus