SORD Antibody – Rabbit Polyclonal

Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]

SORD: Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm. Belongs to the zinc-containing alcohol dehydrogenase family.

Protein type: Carbohydrate Metabolism - fructose and mannose; EC 1.1.1.14; Oxidoreductase

Chromosomal Location of Human Ortholog: 15q21.1

Cellular Component: cytosol; extracellular space; membrane

Molecular Function: D-xylulose reductase activity; identical protein binding; L-iditol 2-dehydrogenase activity; NAD binding; zinc ion binding

Biological Process: fructose biosynthetic process; glucose metabolic process; glucuronate catabolic process to xylulose 5-phosphate; L-xylitol catabolic process; L-xylitol metabolic process; sorbitol catabolic process; sperm motility