OGG1 Antibody – Goat Polyclonal

OGG1: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion. Defects in OGG1 may be a cause of renal cell carcinoma (RCC). It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Belongs to the type-1 OGG1 family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Deoxyribonuclease; Lyase; DNA repair, damage; EC 4.2.99.18

Cellular Component: mitochondrion; nuclear matrix; nuclear speck; nucleoplasm; nucleus; protein complex

Molecular Function: 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity; catalytic activity; damaged DNA binding; DNA binding; DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; DNA-3-methyladenine glycosylase III activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds; lyase activity; microtubule binding; oxidized base lesion DNA N-glycosylase activity; oxidized purine base lesion DNA N-glycosylase activity; oxidized purine DNA binding; purine-specific mismatch base pair DNA N-glycosylase activity; single-strand selective uracil DNA N-glycosylase activity; uracil DNA N-glycosylase activity

Biological Process: aging; base-excision repair; DNA repair; metabolic process; negative regulation of apoptosis; nucleotide-excision repair; nucleotide-excision repair, DNA incision; regulation of protein import into nucleus, translocation; regulation of transcription, DNA-dependent; response to DNA damage stimulus; response to estradiol stimulus; response to oxidative stress; response to radiation