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ALS2CR2/ILPIP (STRADB) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420020

MBS420020 is an antibody targeting STRADB. Also known as Goat anti-ALS2CR2/ILPIP Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Dog, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ALS2CR2/ILPIP (STRADB), Polyclonal Antibody
Full Product Name
Goat anti-ALS2CR2/ILPIP Antibody
Product Gene Name
anti-STRADB antibody
Product Synonym Gene Name
ALS2CR2; ILPIP
Product Synonym Names
STRADB; ALS2CR2; ILPIP; PAPK; ILPIPA; CALS-21; PRO1038; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2; ILP-interacting protein ILPIPA; STE20-related kinase adaptor beta; STRAD beta; pseudokinase ALS2CR2; STRADB antibody; ALS2CR2 antibody; ILPIP antibody; PAPK antibody; ILPIPA antibody; CALS-21 antibody; PRO1038 antibody; amyotrophic lateral sclerosis 2 (juvenile) chromosome region; candidate 2 antibody; ILP-interacting protein ILPIPA antibody; STE20-related kinase adaptor beta antibody; STRAD beta antibody; pseudokinase ALS2CR2 antibody; ALS2CR2 / ILPIP
Immunogen Sequence
CDFPDEKDSY WEF
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Dog, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
ALS2CR2 / ILPIP peptide (MBS426508) is used for blocking the activity of ALS2CR2/ILPIP antibody (MBS420020)
Molecular Weight
31,219 Da
OMIM
607333
Immunogen
Peptide with sequence CDFPDEKDSYWEF, from the C Terminus of the protein sequence according to NP_061041.2; AAF71042.1.
Epitope
C Terminus
Note
This is expected to recognise both human isoforms: ILPIP-alpha (NP_061041.2) and ILPIP-beta (AAF71042.1).
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-STRADB antibody
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-STRADB antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: Immunohistochemistry: In paraffin embedded Human Heart shows staining of myocardial fibres in transverse section. Recommended concentration, 3-5ug/ml.
Western Blot: Approx 35kDa band observed in Human Heart, Liver and Muscle lysates (calculated MW of 47. 0kDa according to NP_061041.2 (alpha isoform) and 31.2kDa according to AAF71042.1(beta isoform). In transfected HEK293 transiently expressing ILPIP a band of approx. 48kDa is observed. This band is not observed in the non-transfected HEK293. Recommended concentration 1-3ug/ml.

Western Blot (WB) of anti-STRADB antibody

(1ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-STRADB Polyclonal Antibody – Cat# MBS420020

Western Blot (WB) of anti-STRADB antibody

HEK293 overexpressing ILPIP (RC203432) and probed (mock transfection in first lane), tested by Origene.
Goat Anti-STRADB Polyclonal Antibody, Western Blot (WB) – Cat# MBS420020

Immunohistochemistry (IHC) of anti-STRADB antibody

(3.8ug/ml) staining of paraffin embedded Human Heart. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Goat Anti-STRADB Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS420020

Other Notes

Small volumes of anti-STRADB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for STRADB. It may not necessarily be applicable to this product.

NCBI GI #
13027388
NCBI GeneID
55437
NCBI Accession #
NP_061041.2
NCBI Related Accession #
AAF71042.1
UniProt Secondary Accession #
Q5BKY7; Q9P1L0
UniProt Related Accession #
Q9C0K7
GenBank Nucleotide #
NM_018571.5
NCBI Official Full Name
STE20-related kinase adapter protein beta isoform 1
NCBI Official Synonym Full Names
STE20-related kinase adaptor beta
NCBI Official Symbol
STRADB
NCBI Official Synonym Symbols
PAPK; ILPIP; ILPIPA; ALS2CR2; CALS-21; PRO1038
UniProt Protein Name
STE20-related kinase adapter protein beta
UniProt Synonym Protein Names
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; CALS-21; ILP-interacting protein; Pseudokinase ALS2CR2
Protein Family
STE20-related kinase adapter protein
UniProt Gene Name
STRADB
UniProt Synonym Gene Names
ALS2CR2; ILPIP; STRAD beta
UniProt Entry Name
STRAB_HUMAN
NCBI Protein Information
STE20-related kinase adapter protein beta

NCBI Summary for STRADB

This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
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UniProt Comments for STRADB

STLK6: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, STE; STE group; STE20 family; STLK subfamily

Chromosomal Location of Human Ortholog: 2q33.1

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: ATP binding; protein binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: activation of protein kinase activity; cell cycle arrest; cell morphogenesis; protein amino acid phosphorylation; protein export from nucleus
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Research Articles on STRADB

1. a novel XIAP-interacting protein that acts as a co-factor enhancing XIAP-mediated activation of JNK1 and the caspase-independent protection of XIAP against apoptosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-STRADB antibody

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway antibodies  Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway Diagram
 IGF1R Signaling Cascade Pathway antibodies  IGF1R Signaling Cascade Pathway Diagram
 IRS-mediated Signalling Pathway antibodies  IRS-mediated Signalling Pathway Diagram
 IRS-related Events Triggered By IGF1R Pathway antibodies  IRS-related Events Triggered By IGF1R Pathway Diagram
 Insulin Receptor Signalling Cascade Pathway antibodies  Insulin Receptor Signalling Cascade Pathway Diagram
 LKB1 Signaling Events Pathway antibodies  LKB1 Signaling Events Pathway Diagram
 PI3K Cascade Pathway antibodies  PI3K Cascade Pathway Diagram

Diseases associated with anti-STRADB antibody

 Disease Name  Pubmed Publications
 Nerve Degeneration Antibodies  >1 publications with STRADB and Nerve Degeneration
 Nervous System Diseases Antibodies  >1 publications with STRADB and Nervous System Diseases

Organs/Tissues associated with anti-STRADB antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with STRADB and Brain
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