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USP11 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420029

MBS420029 is an antibody targeting USP11. Also known as Goat anti-USP11/UHX1 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
USP11/UHX1, Polyclonal Antibody
Full Product Name
Goat anti-USP11/UHX1 Antibody
Product Gene Name
anti-USP11 antibody
Product Synonym Gene Name
UHX1
Product Synonym Names
USP11; UHX1; ubiquitin specific protease 11; deubiquitinating enzyme 11; ubiquitin thiolesterase 11; ubiquitin carboxyl-terminal hydrolase, X-linked; ubiquitin specific peptidase 11; RP4-659F15.2; ubiquitin-specific processing protease 11; USP11 antibody; UHX1 antibody; ubiquitin specific protease 11 antibody; deubiquitinating enzyme 11 antibody; ubiquitin thiolesterase 11 antibody; ubiquitin carboxyl-terminal hydrolase; X-linked antibody; ubiquitin specific peptidase 11 antibody; RP4-659F15.2 antibody; ubiquitin-specific processing protease 11 antibody; USP11 / UHX1
Immunogen Sequence
CSSPPSSEFM DVN
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
USP11 / UHX1 peptide (MBS425225) is used for blocking the activity of USP11/UHX1 antibody (MBS420029)
Molecular Weight
109,817 Da
OMIM
300050
Immunogen
Peptide with sequence CSSPPSSEFMDVN, from the C Terminus of the protein sequence according to NP_004642.2.
Epitope
C Terminus
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-USP11 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-USP11 antibody
Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Approx 120kDa band observed in Human Testis lysates and in lysates of cell line Jurkat (calculated MW of 110kDa according to NP_004642.2). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Ideguchi et al, Biochem J.2002 Oct 1;367(Pt 1): 87-95.; PMID: 12084015). Recommended concentration: 1-3ug/ml.

Western Blot (WB) of anti-USP11 antibody

Staining (1ug/ml) of Jurkat lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Goat Anti-USP11 Polyclonal Antibody – Cat# MBS420029

Other Notes

Small volumes of anti-USP11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for USP11. It may not necessarily be applicable to this product.

NCBI GI #
24234683
NCBI GeneID
8237
NCBI Accession #
NP_004642.2
UniProt Secondary Accession #
Q8IUG6; Q9BWE1; B2RTX1
UniProt Related Accession #
P51784
GenBank Nucleotide #
NM_004651.3
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase 11
NCBI Official Synonym Full Names
ubiquitin specific peptidase 11
NCBI Official Symbol
USP11
NCBI Official Synonym Symbols
UHX1
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase 11
UniProt Synonym Protein Names
Deubiquitinating enzyme 11; Ubiquitin thioesterase 11; Ubiquitin-specific-processing protease 11
Protein Family
Ubiquitin carboxyl-terminal hydrolase
UniProt Gene Name
USP11
UniProt Synonym Gene Names
UHX1
UniProt Entry Name
UBP11_HUMAN
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase 11

NCBI Summary for USP11

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008]
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UniProt Comments for USP11

USP11: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Belongs to the peptidase C19 family.

Protein type: EC 3.4.19.12; Protease; Ubiquitin-specific protease; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: cytoplasm; nucleus

Molecular Function: cysteine-type endopeptidase activity; protein binding; ubiquitin-specific protease activity

Biological Process: protein deubiquitination; ubiquitin-dependent protein catabolic process
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Research Articles on USP11

1. novel insight into cross-talk between ubiquitin and SUMO and uncover USP11 and RNF4 as a balanced SUMO-targeted ubiquitin ligase/protease pair with a role in the DDR.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-USP11 antibody

 Products by Pathway  Pathway Diagram
 Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway antibodies  Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway Diagram
 Chaperonin-mediated Protein Folding Pathway antibodies  Chaperonin-mediated Protein Folding Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Protein Folding Pathway antibodies  Protein Folding Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram

Diseases associated with anti-USP11 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >2 publications with USP11 and Necrosis
 Uterine Cervical Neoplasms Antibodies  >1 publications with USP11 and Uterine Cervical Neoplasms
 Drug Hypersensitivity Antibodies  >1 publications with USP11 and Drug Hypersensitivity
 Hemorrhage Antibodies  >1 publications with USP11 and Hemorrhage
 Kidney Diseases Antibodies  >1 publications with USP11 and Kidney Diseases
 Inflammation Antibodies  >1 publications with USP11 and Inflammation

Organs/Tissues associated with anti-USP11 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with USP11 and Liver
 Eye Antibodies  >2 publications with USP11 and Eye
 Brain Antibodies  >2 publications with USP11 and Brain
 Bone Antibodies  >1 publications with USP11 and Bone
 Blood Antibodies  >1 publications with USP11 and Blood
 Kidney Antibodies  >1 publications with USP11 and Kidney
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