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PITPNM/PITPNM1 (PITPNM1) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420098

MBS420098 is an antibody targeting PITPNM1. Also known as Goat anti-PITPNM/PITPNM1 Antibody. Reactive in Tested: Mouse; Expected from sequence similarity: Human, Mouse, Dog, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PITPNM/PITPNM1, Polyclonal Antibody
Full Product Name
Goat anti-PITPNM/PITPNM1 Antibody
Product Gene Name
anti-PITPNM1 antibody
Product Synonym Gene Name
PITPNM
Product Synonym Names
PITPNM1; PITPNM; NIR2; DRES9; phosphatidylinositol transfer protein, membrane-associated; Drosophila retinal degeneration B; PYK2 N-terminal domain-interacting receptor 2; phosphatidylinositol transfer protein, membrane-associated 1; FLJ44997; RDGB; RDGB1; PITPNM antibody; NIR2 antibody; DRES9 antibody; phosphatidylinositol transfer protein; membrane-associated antibody; Drosophila retinal degeneration B antibody; PYK2 N-terminal domain-interacting receptor 2 antibody; PITPNM1 antibody; FLJ44997 antibody; RDGB antibody; RDGB1 antibody; RDGBA antibody; RDGBA1 antibody; Rd9 antibody; phosphatidylinositol transfer protein; membrane-associated antibody; retinal degeneration B alpha 1 antibody; PITPNM / PITPNM1
Immunogen Sequence
KARSISLKLD SEE
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Mouse; Expected from sequence similarity: Human, Mouse, Dog, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
PITPNM / PITPNM1 peptide (MBS426114) is used for blocking the activity of PITPNM/PITPNM1 antibody (MBS420098)
Molecular Weight
134,777 Da
OMIM
608794
Immunogen
Peptide with sequence C-KARSISLKLDSEE, from the C Terminus of the protein sequence according to NP_004901.2; NP_001124320.1.
Epitope
C Terminus
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-PITPNM1 antibody
Peptide ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)
Application Notes for anti-PITPNM1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Customer's experiments gave a band at approx 160kDa in lysates of a Mouse Macrophage cell line after 2ug/ml antibody staining (calculated MW of 135kDa according to NP_004901.1). In ICC the customer found staining of vesicular cytoplasm in the same cell line.

Other Notes

Small volumes of anti-PITPNM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PITPNM1. It may not necessarily be applicable to this product.

NCBI GI #
195927015
NCBI GeneID
9600
NCBI Accession #
NP_004901.2
NCBI Related Accession #
NP_001124320.1
UniProt Secondary Accession #
Q6T7X3; Q8TBN3; Q9BZ73; A6NME4
UniProt Related Accession #
O00562
GenBank Nucleotide #
NM_004910.2
NCBI Official Full Name
membrane-associated phosphatidylinositol transfer protein 1 isoform a
NCBI Official Synonym Full Names
phosphatidylinositol transfer protein membrane associated 1
NCBI Official Symbol
PITPNM1
NCBI Official Synonym Symbols
Rd9; NIR2; RDGB; DRES9; RDGB1; RDGBA; PITPNM; RDGBA1
UniProt Protein Name
Membrane-associated phosphatidylinositol transfer protein 1
UniProt Synonym Protein Names
Drosophila retinal degeneration B homolog; Phosphatidylinositol transfer protein, membrane-associated 1; PITPnm 1; Pyk2 N-terminal domain-interacting receptor 2; NIR-2
Protein Family
Membrane-associated phosphatidylinositol transfer protein
UniProt Gene Name
PITPNM1
UniProt Synonym Gene Names
DRES9; NIR2; PITPNM; PITPnm 1; NIR-2
UniProt Entry Name
PITM1_HUMAN
NCBI Protein Information
membrane-associated phosphatidylinositol transfer protein 1

NCBI Summary for PITPNM1

PITPNM1 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).[supplied by OMIM, Mar 2008]

UniProt Comments for PITPNM1

PITPNM1: putatively transfers phosphatidylinositol and phosphatidylcholine between membranes. Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Has higher affinity for the inactive, GDP-bound form of RHOA. Necessary for normal completion of cytokinesis and for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions. Interacts with PIK4CA and with Pyk2 via its C-terminus. Phosphorylated on multiple sites by CDC2 at the onset of mitosis. CDC2-phosphorylated forms may interact with PLK1. Interacts with VAPB. Phosphorylated on threonine residues upon treatment with oleic acid.

Protein type: Cell surface

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cleavage furrow; cytoplasm; endoplasmic reticulum membrane; lipid particle; membrane; midbody

Molecular Function: metal ion binding; phosphatidylinositol transporter activity; protein binding

Biological Process: brain development; lipid metabolic process; phospholipid transport; phototransduction; protein transport
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Research Articles on PITPNM1

1. results suggest that Nir2 not only enhances EMT in vitro and breast cancer metastasis in animal models, but also contributes to breast cancer progression in human patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-PITPNM1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >1 publications with PITPNM1 and Breast Neoplasms
 Disease Models, Animal Antibodies  >1 publications with PITPNM1 and Disease Models, Animal

Organs/Tissues associated with anti-PITPNM1 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >20 publications with PITPNM1 and Eye
 Brain Antibodies  >2 publications with PITPNM1 and Brain
 Lung Antibodies  >1 publications with PITPNM1 and Lung
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