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Nogo 66 Receptor (RTN4R) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420106

MBS420106 is an antibody targeting RTN4R. Also known as Goat anti-Nogo 66 receptor Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Pig, Dog. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Nogo 66 receptor (RTN4R), Polyclonal Antibody
Full Product Name
Goat anti-Nogo 66 receptor Antibody
Product Gene Name
anti-RTN4R antibody
Product Synonym Names
RTN4R; Nogo-66 receptor; reticulon 4 receptor; HGNC: 1860; NGR; NOGOR; UNQ330/PRO526; nogo receptor; reticulon 4 receptor precursor; OTTHUMP00000197866; Nogo-66 receptor antibody; RTN4R antibody; reticulon 4 receptor antibody; HGNC: 1860 antibody; NGR antibody; NOGOR antibody; UNQ330/PRO526 antibody; nogo receptor antibody; reticulon 4 receptor precursor antibody; OTTHUMP00000197866 antibody; Nogo 66 receptor; Nogo 66 receptor
Immunogen Sequence
LQALPDDTFR DLGN
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Pig, Dog
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
Nogo 66 receptor peptide (MBS426024) is used for blocking the activity of Nogo 66 receptor antibody (MBS420106)
Molecular Weight
50,708 Da
OMIM
605566
Immunogen
Peptide with sequence C-LQALPDDTFRDLGN, from the internal region of the protein sequence according to NP_075380.1.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-RTN4R antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-RTN4R antibody
Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Experiments gave bands at approx 90-100kDa and 37+40+45kDa in Human brain lysate after 0.3ug/ml antibody staining. These bands were successfully blocked by the immunizing peptide and they correspond to earlier findings in the literature with different antibodies (Wang et al, J Neurosci.2002 Jul 1;22(13): 5505-15). This protein has a calculated MW of 50.7kDa according to NP_075380.1. Recommended concentration: 0.3-1ug/ml.

Western Blot (WB) of anti-RTN4R antibody

(0.3ug/ml) staining of Human Brain lysate (35ug protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide. Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-RTN4R Polyclonal Antibody – Cat# MBS420106

Other Notes

Small volumes of anti-RTN4R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RTN4R. It may not necessarily be applicable to this product.

NCBI GI #
13194201
NCBI GeneID
65078
NCBI Accession #
NP_075380.1
UniProt Secondary Accession #
D3DX28
UniProt Related Accession #
Q9BZR6
GenBank Nucleotide #
NM_023004.5
NCBI Official Full Name
reticulon-4 receptor
NCBI Official Synonym Full Names
reticulon 4 receptor
NCBI Official Symbol
RTN4R
NCBI Official Synonym Symbols
NGR; NOGOR
UniProt Protein Name
Reticulon-4 receptor
UniProt Synonym Protein Names
Nogo receptor; NgR; Nogo-66 receptor
Protein Family
Reticulon-4 receptor
UniProt Gene Name
RTN4R
UniProt Synonym Gene Names
NOGOR; NgR
UniProt Entry Name
RTN4R_HUMAN
NCBI Protein Information
reticulon-4 receptor

NCBI Summary for RTN4R

This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]
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UniProt Comments for RTN4R

RTN4R: Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development. Belongs to the Nogo receptor family.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: cell soma; cell surface; cytoplasm; endoplasmic reticulum; integral to plasma membrane; neuron projection; plasma membrane

Molecular Function: protein binding; protein kinase inhibitor activity

Biological Process: cytokine and chemokine mediated signaling pathway; negative regulation of axon extension; negative regulation of axonogenesis; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; positive regulation of GTPase activity

Disease: Schizophrenia
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Research Articles on RTN4R

1. Authors highlight the structural and biochemical aspects of the interaction of Nogo receptors (R1 and R2) with myelin inhibitors such as MAG, Nogo A and OMgp.[Review]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RTN4R antibody

 Reference Product  PubMed Publications
 RTN4 antibody  >118 publications with RTN4R and RTN4
 MAG antibody  >51 publications with RTN4R and MAG
 RHOA antibody  >30 publications with RTN4R and RHOA
 OMG antibody  >19 publications with RTN4R and OMG
 LINGO1 antibody  >14 publications with RTN4R and LINGO1
 NGFR antibody  >4 publications with RTN4R and NGFR
 KIAA0319L antibody  >1 publications with RTN4R and KIAA0319L

Pathways associated with anti-RTN4R antibody

 Products by Pathway  Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 P75(NTR)-mediated Signaling Pathway antibodies  P75(NTR)-mediated Signaling Pathway Diagram

Diseases associated with anti-RTN4R antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >114 publications with RTN4R and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >25 publications with RTN4R and Cardiovascular Diseases
 Necrosis Antibodies  >17 publications with RTN4R and Necrosis
 Immune System Diseases Antibodies  >12 publications with RTN4R and Immune System Diseases
 Schizophrenia Antibodies  >11 publications with RTN4R and Schizophrenia
 Nerve Degeneration Antibodies  >9 publications with RTN4R and Nerve Degeneration
 Inflammation Antibodies  >6 publications with RTN4R and Inflammation
 Learning Disorders Antibodies  >5 publications with RTN4R and Learning Disorders
 Neurobehavioral Manifestations Antibodies  >5 publications with RTN4R and Neurobehavioral Manifestations
 Edema Antibodies  >5 publications with RTN4R and Edema

Organs/Tissues associated with anti-RTN4R antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >136 publications with RTN4R and Brain
 Eye Antibodies  >16 publications with RTN4R and Eye
 Blood Antibodies  >13 publications with RTN4R and Blood
 Embryonic Tissue Antibodies  >9 publications with RTN4R and Embryonic Tissue
 Bone Antibodies  >4 publications with RTN4R and Bone
 Kidney Antibodies  >3 publications with RTN4R and Kidney
 Thymus Antibodies  >1 publications with RTN4R and Thymus
 Lymph Node Antibodies  >1 publications with RTN4R and Lymph Node
 Lung Antibodies  >1 publications with RTN4R and Lung
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