SLC22A16 Antibody – Goat Polyclonal

This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]

SLC22A16: High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Motility/polarity/chemotaxis; Transporter, SLC family

Chromosomal Location of Human Ortholog: 6q22.1|6q21-q22.1

Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function: amine transmembrane transporter activity; carnitine transporter activity; organic cation transmembrane transporter activity

Biological Process: acid secretion; amine transport; carnitine transport; cell differentiation; multicellular organismal development; organic cation transport; single fertilization; sperm motility; spermatogenesis