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SLC24A5 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420180

MBS420180 is an antibody targeting SLC24A5. Also known as Goat anti-SLC24A5 Antibody. Reactive in Tested: Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SLC24A5, Polyclonal Antibody
Full Product Name
Goat anti-SLC24A5 Antibody
Product Gene Name
anti-SLC24A5 antibody
Product Synonym Names
SLC24A5; solute carrier family 24,member 5; JSX; NCKX5; ion transporter JSX; solute carrier family 24 (sodium/potassium/calcium exchanger),member 5; SLC24A5 antibody; solute carrier family 24; member 5 antibody; JSX antibody; NCKX5 antibody; ion transporter JSX antibody; solute carrier family 24 (sodium/potassium/calcium exchanger); member 5 antibody
Immunogen Sequence
TTPDCRKKFW KN
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
SLC24A5 peptide (MBS426349) is used for blocking the activity of SLC24A5 antibody (MBS420180)
Molecular Weight
48,016 Da
OMIM
113750
Immunogen
Peptide with sequence TTPDCRKKFWKN, from the internal region of the protein sequence according to NP_995322.1.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-SLC24A5 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-SLC24A5 antibody
Peptide ELISA: Antibody detection limit dilution 1: 2000.
Western Blot: Approx 40kDa band observed in Mouse Eye and Rat Skin lysates (calculated MW of 54.9 according to Human NP_995322.1, of 55. 0kDa according to Mouse NP_778199.2 and of 38.1kDa according to Rat NP_001101239.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Ginger et al, J Biol Chem.2008 Feb 29;283(9): 5486-95; PMID: 18166528). Recommended concentration: 1-3ug/ml.

Western Blot (WB) of anti-SLC24A5 antibody

(2ug/ml) staining of Mouse Eye lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-SLC24A5 Polyclonal Antibody – Cat# MBS420180

Other Notes

Small volumes of anti-SLC24A5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC24A5. It may not necessarily be applicable to this product.

NCBI GI #
45504369
NCBI GeneID
283652
NCBI Accession #
NP_995322.1
UniProt Secondary Accession #
Q14CT4; Q6DKH3; A5X8Z8; A5X8Z9
UniProt Related Accession #
Q71RS6
GenBank Nucleotide #
NM_205850.2
NCBI Official Full Name
sodium/potassium/calcium exchanger 5
NCBI Official Synonym Full Names
solute carrier family 24 member 5
NCBI Official Symbol
SLC24A5
NCBI Official Synonym Symbols
JSX; OCA6; NCKX5; SHEP4
UniProt Protein Name
Sodium/potassium/calcium exchanger 5
UniProt Synonym Protein Names
Na(+)/K(+)/Ca(2+)-exchange protein 5; Solute carrier family 24 member 5
Protein Family
Sodium/potassium/calcium exchanger
UniProt Gene Name
SLC24A5
UniProt Synonym Gene Names
JSX; NCKX5
UniProt Entry Name
NCKX5_HUMAN
NCBI Protein Information
sodium/potassium/calcium exchanger 5

NCBI Summary for SLC24A5

This gene is a member of the potassium-dependent sodium/calcium exchanger family and encodes an intracellular membrane protein with 2 large hydrophilic loops and 2 sets of multiple transmembrane-spanning segments. Sequence variation in this gene has been associated with differences in skin pigmentation. [provided by RefSeq, Jul 2008]
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UniProt Comments for SLC24A5

SLC24A5: Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.

Protein type: Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q21.1

Cellular Component: integral to plasma membrane; melanosome; trans-Golgi network; trans-Golgi network membrane

Molecular Function: calcium channel activity; calcium ion binding; calcium, potassium:sodium antiporter activity; potassium ion binding; sodium ion binding; symporter activity

Biological Process: cellular calcium ion homeostasis; ion transport; negative regulation of melanin biosynthetic process; potassium ion transport; response to stimulus

Disease: Skin/hair/eye Pigmentation, Variation In, 4
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Research Articles on SLC24A5

1. the SLC24A5 gene locus known to be associated with skin pigmentation was in the top selection signals in the Wolaita, and the alleles of single-nucleotide polymorphisms rs1426654 and rs1834640 (SLC24A5) associated with light skin pigmentation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SLC24A5 antibody

 Products by Pathway  Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Sodium/Calcium Exchangers Pathway antibodies  Sodium/Calcium Exchangers Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram

Diseases associated with anti-SLC24A5 antibody

 Disease Name  Pubmed Publications
 Skin Neoplasms Antibodies  >2 publications with SLC24A5 and Skin Neoplasms
 Insulin Resistance Antibodies  >1 publications with SLC24A5 and Insulin Resistance
 Diabetes Mellitus Antibodies  >1 publications with SLC24A5 and Diabetes Mellitus
 Hypertension Antibodies  >1 publications with SLC24A5 and Hypertension
 Carcinoma Antibodies  >1 publications with SLC24A5 and Carcinoma
 Atherosclerosis Antibodies  >1 publications with SLC24A5 and Atherosclerosis
 Immune System Diseases Antibodies  >1 publications with SLC24A5 and Immune System Diseases
 Vascular Diseases Antibodies  >1 publications with SLC24A5 and Vascular Diseases
 Prostatic Neoplasms Antibodies  >1 publications with SLC24A5 and Prostatic Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with SLC24A5 and Neoplasms, Experimental

Organs/Tissues associated with anti-SLC24A5 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >64 publications with SLC24A5 and Skin
 Kidney Antibodies  >1 publications with SLC24A5 and Kidney
 Prostate Antibodies  >1 publications with SLC24A5 and Prostate
 Brain Antibodies  >1 publications with SLC24A5 and Brain
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