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DAPK2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420208

MBS420208 is an antibody targeting DAPK2. Also known as Goat anti-DAPK2 Antibody. Reactive in Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DAPK2, Polyclonal Antibody
Full Product Name
Goat anti-DAPK2 Antibody
Product Gene Name
anti-DAPK2 antibody
Product Synonym Names
DAPK2; death-associated protein kinase 2; DRP-1; DRP1; MGC119312; DAP kinase 2; DAP-kinase-related protein 1; OTTHUMP00000163874; death-associated kinase 2; DAPK2 antibody; death-associated protein kinase 2 antibody; DRP-1 antibody; DRP1 antibody; MGC119312 antibody; DAP kinase 2 antibody; DAP-kinase-related protein 1 antibody; OTTHUMP00000163874 antibody; death-associated kinase 2 antibody
Immunogen Sequence
KALHPRRRSS TS
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
DAPK2 peptide (MBS425858) is used for blocking the activity of DAPK2 antibody (MBS420208)
Molecular Weight
55,931 Da
OMIM
616567
Immunogen
Peptide with sequence C-KALHPRRRSSTS, from the C Terminus of the protein sequence according to NP_055141.2.
Epitope
C Terminus
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-DAPK2 antibody
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-DAPK2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: Immunohistochemistry: In paraffin embedded Human Breast shows staining of the luminar side of the cell membranes of epithelial cells in the ducts. Recommended concentration, 2-4ug/ml.
Western Blot: Approx 40-45kDa bands seen in mouse brain extracts. Recommended for use at 1-3ug/ml.

Western Blot (WB) of anti-DAPK2 antibody

Staining (2ug/ml) of mouse brain extracts (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Goat Anti-DAPK2 Polyclonal Antibody – Cat# MBS420208

Immunohistochemistry (IHC) of anti-DAPK2 antibody

(2.5ug/ml) staining of paraffin embedded Human Breast. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Goat Anti-DAPK2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS420208

Other Notes

Small volumes of anti-DAPK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DAPK2. It may not necessarily be applicable to this product.

NCBI GI #
14670383
NCBI GeneID
23604
NCBI Accession #
NP_055141.2
UniProt Secondary Accession #
O75892; Q24JS1; E9JGM7
UniProt Related Accession #
Q9UIK4
GenBank Nucleotide #
NM_014326.3
NCBI Official Full Name
death-associated protein kinase 2
NCBI Official Synonym Full Names
death-associated protein kinase 2
NCBI Official Symbol
DAPK2
NCBI Official Synonym Symbols
DRP1; DRP-1
UniProt Protein Name
Death-associated protein kinase 2
UniProt Synonym Protein Names
DAP-kinase-related protein 1; DRP-1
Protein Family
Death-associated protein kinase
UniProt Gene Name
DAPK2
UniProt Synonym Gene Names
DAP kinase 2; DRP-1
UniProt Entry Name
DAPK2_HUMAN
NCBI Protein Information
death-associated protein kinase 2

NCBI Summary for DAPK2

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
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UniProt Comments for DAPK2

DAPK2: an ubiquitously expressed protein kinase of the DAPK family. Activated by Ca(2+)/calmodulin. Contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain. Overexpression induces apoptosis. Expressed at high levels in heart, lung and skeletal muscle.

Protein type: Protein kinase, CAMK; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); CAMK group; DAPK family

Chromosomal Location of Human Ortholog: 15q22.31

Cellular Component: cytoplasm; cytoplasmic vesicle

Molecular Function: ATP binding; calmodulin binding; identical protein binding; protein binding; protein serine/threonine kinase activity

Biological Process: anoikis; apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of autophagy
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Research Articles on DAPK2

1. that Death-associated protein kinase 2 effector functions are influenced by the protein's subcellular localization

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DAPK2 antibody

 Reference Product  PubMed Publications
 DAP antibody  >149 publications with DAPK2 and DAP
 ATF4 antibody  >4 publications with DAPK2 and ATF4
 CAMK2A antibody  >1 publications with DAPK2 and CAMK2A

Pathways associated with anti-DAPK2 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Caspase Activation Via Extrinsic Apoptotic Signalig Pathway antibodies  Caspase Activation Via Extrinsic Apoptotic Signalig Pathway Diagram
 Ligand-independent Caspase Activation Via DCC Pathway antibodies  Ligand-independent Caspase Activation Via DCC Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Programmed Cell Death Pathway antibodies  Programmed Cell Death Pathway Diagram

Diseases associated with anti-DAPK2 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >69 publications with DAPK2 and Brain Diseases
 Necrosis Antibodies  >62 publications with DAPK2 and Necrosis
 Carcinoma, Squamous Cell Antibodies  >59 publications with DAPK2 and Carcinoma, Squamous Cell
 Neoplasm Metastasis Antibodies  >42 publications with DAPK2 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >36 publications with DAPK2 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >36 publications with DAPK2 and Neoplasms, Experimental
 Inflammation Antibodies  >35 publications with DAPK2 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >27 publications with DAPK2 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >26 publications with DAPK2 and Disease Models, Animal
 Urinary Bladder Neoplasms Antibodies  >14 publications with DAPK2 and Urinary Bladder Neoplasms

Organs/Tissues associated with anti-DAPK2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >107 publications with DAPK2 and Blood
 Brain Antibodies  >81 publications with DAPK2 and Brain
 Lung Antibodies  >75 publications with DAPK2 and Lung
 Vascular Antibodies  >40 publications with DAPK2 and Vascular
 Stomach Antibodies  >32 publications with DAPK2 and Stomach
 Lymph Node Antibodies  >30 publications with DAPK2 and Lymph Node
 Bone Marrow Antibodies  >20 publications with DAPK2 and Bone Marrow
 Prostate Antibodies  >17 publications with DAPK2 and Prostate
 Skin Antibodies  >11 publications with DAPK2 and Skin
 Intestine Antibodies  >9 publications with DAPK2 and Intestine
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