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TCFEC Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420251

MBS420251 is an antibody targeting Tcfec. Also known as Goat anti-Tcfec (mouse) Antibody. Reactive in Expected from sequence similarity: Mouse, Rat. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tcfec, Polyclonal Antibody
Full Product Name
Goat anti-Tcfec (mouse) Antibody
Product Gene Name
anti-Tcfec antibody
Product Synonym Names
Tcfec; transcription factor EC; BB107417; MGC107474; TFEC; Tcfec antibody; transcription factor EC antibody; BB107417 antibody; MGC107474 antibody; TFEC antibody; Tcfec (mouse)
Immunogen Sequence
HITKQQTHPE RN
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Mouse, Rat
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
Tcfec peptide (MBS426849) is used for blocking the activity of Tcfec antibody (MBS420251)
Molecular Weight
35,144 Da
Immunogen
Peptide with sequence C-HITKQQTHPERN, from the internal region of the protein sequence according to NP_112475.1.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-Tcfec antibody
Peptide ELISA (EIA)
Application Notes for anti-Tcfec antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Preliminary experiments gave one band at approx 37kDa and much stronger bands at approx 70+28kDa in Mouse Testis lysates after 0.5 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the stonger bands we observe given the calculated size of 35.1kDa according to Mouse NP_112475.1. All detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).

Other Notes

Small volumes of anti-Tcfec antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Tcfec. It may not necessarily be applicable to this product.

NCBI GI #
13654264
NCBI GeneID
21426
NCBI Accession #
NP_112475.1
UniProt Secondary Accession #
Q3TWR7
UniProt Related Accession #
Q9WTW4
GenBank Nucleotide #
NM_031198.3
NCBI Official Full Name
transcription factor EC
NCBI Official Synonym Full Names
transcription factor EC
NCBI Official Symbol
Tfec
NCBI Official Synonym Symbols
Tcfec; bHLHe34; BB107417
UniProt Protein Name
Transcription factor EC
UniProt Gene Name
Tfec
UniProt Synonym Gene Names
Tcfec; TFE-C; mTFEC
UniProt Entry Name
TFEC_MOUSE
NCBI Protein Information
transcription factor EC

UniProt Comments for Tcfec

TFEC: Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence. Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer. Binds DNA in a homo- or heterodimeric form. Belongs to the MiT/TFE family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: DNA binding; protein dimerization activity

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
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Research Articles on Tcfec

1. Data indicate that FOS, SPI1, KLF10, TFEC, and PRDM16 show robust transcriptional cross-regulation and are often associated with osteoclastogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Tcfec antibody

 Reference Product  PubMed Publications
 Vsx2 antibody  >2 publications with Tcfec and Vsx2

Diseases associated with anti-Tcfec antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >9 publications with Tcfec and Kidney Diseases
 Necrosis Antibodies  >7 publications with Tcfec and Necrosis
 Acute Kidney Injury Antibodies  >2 publications with Tcfec and Acute Kidney Injury
 Drug-Induced Liver Injury Antibodies  >2 publications with Tcfec and Drug-Induced Liver Injury
 Growth Disorders Antibodies  >1 publications with Tcfec and Growth Disorders
 Atrophy Antibodies  >1 publications with Tcfec and Atrophy
 Liver Diseases Antibodies  >1 publications with Tcfec and Liver Diseases
 Anemia Antibodies  >1 publications with Tcfec and Anemia
 Lung Diseases Antibodies  >1 publications with Tcfec and Lung Diseases
 Vascular Diseases Antibodies  >1 publications with Tcfec and Vascular Diseases

Organs/Tissues associated with anti-Tcfec antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >32 publications with Tcfec and Kidney
 Blood Antibodies  >6 publications with Tcfec and Blood
 Bone Antibodies  >4 publications with Tcfec and Bone
 Embryonic Tissue Antibodies  >2 publications with Tcfec and Embryonic Tissue
 Bone Marrow Antibodies  >2 publications with Tcfec and Bone Marrow
 Spleen Antibodies  >1 publications with Tcfec and Spleen
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