• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

RXR Beta (RXRB) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420305

MBS420305 is an antibody targeting RXRB. Also known as Goat anti-RXR beta Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RXR beta (RXRB), Polyclonal Antibody
Full Product Name
Goat anti-RXR beta Antibody
Product Gene Name
anti-RXRB antibody
Product Synonym Gene Name
RXR beta
Product Synonym Names
RXRB; NR2B2; DAUDI6; RCoR-1; MGC1831; H-2RIIBP; retinoid X receptor, beta; MHC class I promoter binding protein; DADB-100D22.1; RXRB antibody; NR2B2 antibody; DAUDI6 antibody; RCoR-1 antibody; MGC1831 antibody; H-2RIIBP antibody; retinoid X receptor; beta antibody; MHC class I promoter binding protein antibody; DADB-100D22.1 antibody; RXR beta
Immunogen Sequence
CRDGMGDSGR DSRSP
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
RXR beta peptide (MBS426166) is used for blocking the activity of RXR beta antibody (MBS420305)
Molecular Weight
57,365 Da
OMIM
180246
Immunogen
Peptide with sequence CRDGMGDSGRDSRSP, from the internal region of the protein sequence according to NP_068811.1.
Epitope
Internal region
Note
This antibody is expected to recognise an epitope corresponding to aa 70-83 of human RXR beta protein and does not cross-react with either RXR alpha or gamma.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-RXRB antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-RXRB antibody
Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 55kDa band observed in lysates of cell line A431 (calculated MW of 56.9kDa according to NP_068811.1). In transfected HEK293 transiently expressing RXRB a band of approx. 60kDa is observed. This band is not observed in the non-transfected HEK293. Recommended concentration: 1-3ug/ml.

Western Blot (WB) of anti-RXRB antibody

Staining (1ug/ml) of A431 lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Goat Anti-RXRB Polyclonal Antibody – Cat# MBS420305

Western Blot (WB) of anti-RXRB antibody

HEK293 overexpressing RXRB (RC200516) and probed (mock transfection in first lane), tested by Origene.
Goat Anti-RXRB Polyclonal Antibody, Western Blot (WB) – Cat# MBS420305

Other Notes

Small volumes of anti-RXRB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RXRB. It may not necessarily be applicable to this product.

NCBI GI #
11415052
NCBI GeneID
6257
NCBI Accession #
NP_068811.1
UniProt Secondary Accession #
P28703; Q59G65; Q5JP92; Q5STQ1
UniProt Related Accession #
P28702
GenBank Nucleotide #
NM_021976.4
NCBI Official Full Name
retinoic acid receptor RXR-beta isoform 2
NCBI Official Synonym Full Names
retinoid X receptor beta
NCBI Official Symbol
RXRB
NCBI Official Synonym Symbols
NR2B2; DAUDI6; RCoR-1; H-2RIIBP
UniProt Protein Name
Retinoic acid receptor RXR-beta
UniProt Synonym Protein Names
Nuclear receptor subfamily 2 group B member 2; Retinoid X receptor beta
Protein Family
Retinoic acid receptor
UniProt Gene Name
RXRB
UniProt Synonym Gene Names
NR2B2
UniProt Entry Name
RXRB_HUMAN
NCBI Protein Information
retinoic acid receptor RXR-beta

NCBI Summary for RXRB

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Show more

UniProt Comments for RXRB

RXRB: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. Specifically binds 9-cis retinoic acid (9C-RA). Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Expressed in a variety of tumor cell lines. Belongs to the nuclear hormone receptor family. NR2 subfamily.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: nucleoplasm; nucleus

Molecular Function: ligand-dependent nuclear receptor activity; protein binding; protein heterodimerization activity; retinoic acid receptor binding; retinoid-X receptor activity; steroid hormone receptor activity; thyroid hormone receptor binding; thyroid hormone receptor coactivator activity; transcription coactivator activity; transcription factor activity; vitamin D receptor binding; zinc ion binding

Biological Process: positive regulation of transcription from RNA polymerase II promoter; regulation of myelination; retinoic acid receptor signaling pathway; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter
Show more

Research Articles on RXRB

1. RXR interaction is necessary for NPM-RAR-mediated myeloid maturation arrest.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RXRB antibody

 Reference Product  PubMed Publications
 RARB antibody  >5 publications with RXRB and RARB
 RARS antibody  >4 publications with RXRB and RARS
 NR4A2 antibody  >2 publications with RXRB and NR4A2
 NCOA3 antibody  >1 publications with RXRB and NCOA3
 RGL2 antibody  >1 publications with RXRB and RGL2

Pathways associated with anti-RXRB antibody

 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram

Diseases associated with anti-RXRB antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4 publications with RXRB and Inflammation
 Genital Diseases, Male Antibodies  >4 publications with RXRB and Genital Diseases, Male
 Disease Models, Animal Antibodies  >2 publications with RXRB and Disease Models, Animal
 Lung Neoplasms Antibodies  >2 publications with RXRB and Lung Neoplasms
 Prostatic Neoplasms Antibodies  >2 publications with RXRB and Prostatic Neoplasms
 Necrosis Antibodies  >2 publications with RXRB and Necrosis
 Testicular Diseases Antibodies  >1 publications with RXRB and Testicular Diseases
 Atherosclerosis Antibodies  >1 publications with RXRB and Atherosclerosis
 Oligospermia Antibodies  >1 publications with RXRB and Oligospermia
 Obesity Antibodies  >1 publications with RXRB and Obesity

Organs/Tissues associated with anti-RXRB antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with RXRB and Blood
 Thyroid Antibodies  >10 publications with RXRB and Thyroid
 Liver Antibodies  >5 publications with RXRB and Liver
 Testis Antibodies  >4 publications with RXRB and Testis
 Lung Antibodies  >3 publications with RXRB and Lung
 Placenta Antibodies  >2 publications with RXRB and Placenta
 Uterus Antibodies  >2 publications with RXRB and Uterus
 Prostate Antibodies  >2 publications with RXRB and Prostate
 Embryonic Tissue Antibodies  >2 publications with RXRB and Embryonic Tissue
 Heart Antibodies  >2 publications with RXRB and Heart
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000