Homeobox A5 (HOXA5) Antibody – Goat Polyclonal

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]

HOXA5: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'. Belongs to the Antp homeobox family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 7p15.2

Cellular Component: nucleus

Molecular Function: DNA binding; protein binding; transcription factor activity

Biological Process: alveolus development; anterior/posterior pattern formation; cell migration; embryonic skeletal morphogenesis; multicellular organism growth; negative regulation of angiogenesis; negative regulation of erythrocyte differentiation; positive regulation of apoptosis; positive regulation of myeloid cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of mammary gland epithelial cell proliferation; respiratory system process; thyroid gland development; transcription from RNA polymerase II promoter