SMARCA3 (HLTF) Antibody – Goat Polyclonal

This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq, Jul 2008]

SMARCA3: an enzyme with apparent ATP-dependent DNA helicase activity. Belongs to the SNF2/RAD54 helicase family, RAD16 subfamily. Two alternatively spliced human isoforms have been described.

Protein type: EC 3.6.1.-; EC 6.3.2.19; Ligase; Ubiquitin ligase; DNA-binding; Nucleolus; Ubiquitin conjugating system; EC 6.3.2.-; EC 3.6.4.-; Helicase

Chromosomal Location of Human Ortholog: 3q25.1-q26.1

Cellular Component: cytoplasm; membrane; nucleolus; nucleoplasm; nucleus

Molecular Function: ATP binding; ATPase activity; DNA binding; helicase activity; ligase activity; protein binding; ubiquitin protein ligase binding; zinc ion binding

Biological Process: chromatin modification; positive regulation of transcription from RNA polymerase II promoter; postreplication repair; protein polyubiquitination; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter