AKAP6 Antibody – Goat Polyclonal

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq, Jul 2008]

AKAP6: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 14q12

Cellular Component: caveola; cytoplasm; nuclear envelope; nuclear membrane; perinuclear region of cytoplasm; sarcoplasmic reticulum; T-tubule

Molecular Function: adenylate cyclase binding; protein anchor; protein binding; protein complex scaffold; protein kinase A binding

Biological Process: cAMP-mediated signaling; negative regulation of cAMP biosynthetic process; positive regulation of cell growth; positive regulation of NFAT protein import into nucleus; positive regulation of protein phosphatase type 2B activity; positive regulation of release of sequestered calcium ion into cytosol; protein targeting; regulation of action potential