Goat Anti-CDX2 Polyclonal Antibody – Cat# MBS420404

(1ug/ml) staining of Human Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

CDX2 Antibody – Goat Polyclonal

Name: CDX2 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS420404
Price: 450 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420404

MBS420404 is an antibody targeting CDX2. Also known as Goat anti-CDX2 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CDX2, Polyclonal Antibody

Full Product Name

Goat anti-CDX2 Antibody

Product Gene Name

anti-CDX2 antibody

Product Synonym Names

CDX2; caudal type homeo box transcription factor 2; HGNC: 1806; CDX-3; CDX3; CDX2 antibody; caudal type homeo box transcription factor 2 antibody; HGNC: 1806 antibody; CDX-3 antibody; CDX3 antibody

Immunogen Sequence

EQLSPGGQRR NLCE

Clonality

Polyclonal

Host

Goat

Species Reactivity

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Antibody/Peptide Pairs

CDX2 peptide (MBS426000) is used for blocking the activity of CDX2 antibody (MBS420404)

Molecular Weight

33,520 Da

OMIM

600297

Immunogen

Peptide with sequence EQLSPGGQRRNLCE, from the internal region of the protein sequence according to NP_001256.1.

Epitope

Internal region

Note

No cross-reactivity expected with CDX1 and 4

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-CDX2 antibody

Peptide ELISA (EIA), Western Blot (WB)

Application Notes for anti-CDX2 antibody

Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Approx 38kDa band observed in Human Kidney and Liver lysates (calculated MW of 33.5kDa according to NP_001256.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Qualtrough et al Gut.2002 Aug;51(2): 184-90; PMID: 12117877). Recommended concentration: 1-3ug/ml.

Other Notes

Small volumes of anti-CDX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CDX2. It may not necessarily be applicable to this product.

NCBI GI #

4502765

NCBI GeneID

1045

NCBI Accession #

NP_001256.1

UniProt Secondary Accession #

O00503; Q5VTU7; Q969L8; Q9UD92

UniProt Related Accession #

Q99626

GenBank Nucleotide #

NM_001265.2

NCBI Official Full Name

caudal type homeobox 2

NCBI Official Synonym Full Names

caudal type homeobox 2

NCBI Official Symbol

CDX2

NCBI Official Synonym Symbols

CDX3; CDX-3; CDX2/AS

UniProt Protein Name

Homeobox protein CDX-2

UniProt Synonym Protein Names

CDX-3; Caudal-type homeobox protein 2

Protein Family

Homeobox protein

UniProt Gene Name

CDX2

UniProt Synonym Gene Names

CDX3

UniProt Entry Name

CDX2_HUMAN

NCBI Protein Information

homeobox protein CDX-2

NCBI Summary for CDX2

This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]

UniProt Comments for CDX2

CDX2: Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Belongs to the Caudal homeobox family.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: condensed nuclear chromosome; nucleoplasm; nucleus; transcriptional repressor complex

Molecular Function: transcription corepressor activity; transcription factor activity

Biological Process: anterior/posterior axis specification; blood vessel development; cell differentiation; endosome to lysosome transport; establishment and/or maintenance of epithelial cell polarity; negative regulation of transcription from RNA polymerase II promoter; organ morphogenesis; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of transcription, DNA-dependent; regulation of somitogenesis; somatic stem cell maintenance; transcription from RNA polymerase II promoter; trophectodermal cell differentiation

Research Articles on CDX2

1. Lack of CDX2 expression identified a subgroup of patients with high-risk stage II colon cancer who appeared to benefit from adjuvant chemotherapy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDX2 antibody

Reference Product	PubMed Publications
MUC2 antibody	>250 publications with CDX2 and MUC2
SOX2 antibody	>111 publications with CDX2 and SOX2
POU5F1 antibody	>90 publications with CDX2 and POU5F1
KRAS antibody	>45 publications with CDX2 and KRAS
HNF1A antibody	>28 publications with CDX2 and HNF1A
FGF4 antibody	>20 publications with CDX2 and FGF4
NRAS antibody	>3 publications with CDX2 and NRAS
GCG antibody	>2 publications with CDX2 and GCG
HRAS antibody	>1 publications with CDX2 and HRAS

Pathways associated with anti-CDX2 antibody

Products by Pathway	Pathway Diagram
Incretin Synthesis, Secretion, And Inactivation Pathway antibodies	Incretin Synthesis, Secretion, And Inactivation Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Peptide Hormone Metabolism Pathway antibodies	Peptide Hormone Metabolism Pathway Diagram
Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway antibodies	Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway Diagram

Diseases associated with anti-CDX2 antibody

Disease Name	Pubmed Publications
Carcinoma Antibodies	>575 publications with CDX2 and Carcinoma
Neoplasm Metastasis Antibodies	>98 publications with CDX2 and Neoplasm Metastasis
Head and Neck Neoplasms Antibodies	>80 publications with CDX2 and Head and Neck Neoplasms
Lung Neoplasms Antibodies	>78 publications with CDX2 and Lung Neoplasms
Liver Neoplasms Antibodies	>75 publications with CDX2 and Liver Neoplasms
Ovarian Neoplasms Antibodies	>59 publications with CDX2 and Ovarian Neoplasms
Inflammation Antibodies	>55 publications with CDX2 and Inflammation
Breast Neoplasms Antibodies	>46 publications with CDX2 and Breast Neoplasms
Carcinoma, Squamous Cell Antibodies	>41 publications with CDX2 and Carcinoma, Squamous Cell
Liver Diseases Antibodies	>34 publications with CDX2 and Liver Diseases

Organs/Tissues associated with anti-CDX2 antibody

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>431 publications with CDX2 and Intestine
Liver Antibodies	>129 publications with CDX2 and Liver
Embryonic Tissue Antibodies	>95 publications with CDX2 and Embryonic Tissue
Ascites Antibodies	>6 publications with CDX2 and Ascites
Uncharacterized Tissue Antibodies	>2 publications with CDX2 and Uncharacterized Tissue