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IGFBP6 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420496

MBS420496 is an antibody targeting IGFBP6. Also known as Goat anti-IGFBP6 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IGFBP6, Polyclonal Antibody
Full Product Name
Goat anti-IGFBP6 Antibody
Product Gene Name
anti-IGFBP6 antibody
Product Synonym Names
IGFBP6; insulin-like growth factor binding protein 6; IBP6; IGF binding protein 6; IGFBP6 antibody; insulin-like growth factor binding protein 6 antibody; IBP6 antibody; IGF binding protein 6 antibody
Immunogen Sequence
RPQDVNRRDQ QRNP
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
IGFBP6 peptide (MBS426255) is used for blocking the activity of IGFBP6 antibody (MBS420496)
Molecular Weight
25,322 Da
OMIM
146735
Immunogen
Peptide with sequence C-RPQDVNRRDQQRNP, from the internal region of the protein sequence according to NP_002169.1.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-IGFBP6 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-IGFBP6 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx.25kDa band observed in Human Adrenal Gland lysates (calculated MW of 25.3kDa according to NP_002169.1). In transfected HEK293 transiently expressing IGFBP6 a band of approx.29kDa is observed. This band is not observed in the non-transfected HEK293. Recommended concentration: 0.5-1.5ug/ml.

Western Blot (WB) of anti-IGFBP6 antibody

(0.5ug/ml) staining of Human Adrenal Gland lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-IGFBP6 Polyclonal Antibody – Cat# MBS420496

Western Blot (WB) of anti-IGFBP6 antibody

HEK293 overexpressing IGFBP6 (RC204060) and probed (mock transfection in first lane), tested by Origene.
Goat Anti-IGFBP6 Polyclonal Antibody, Western Blot (WB) – Cat# MBS420496

Other Notes

Small volumes of anti-IGFBP6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IGFBP6. It may not necessarily be applicable to this product.

NCBI GI #
11321593
NCBI GeneID
3489
NCBI Accession #
NP_002169.1
UniProt Secondary Accession #
Q14492
UniProt Related Accession #
P24592
GenBank Nucleotide #
NM_002178.2
NCBI Official Full Name
insulin-like growth factor-binding protein 6
NCBI Official Synonym Full Names
insulin like growth factor binding protein 6
NCBI Official Symbol
IGFBP6
NCBI Official Synonym Symbols
IBP6
UniProt Protein Name
Insulin-like growth factor-binding protein 6
Protein Family
Insulin-like growth factor-binding protein
UniProt Gene Name
IGFBP6
UniProt Synonym Gene Names
IBP6; IBP-6; IGF-binding protein 6; IGFBP-6
UniProt Entry Name
IBP6_HUMAN
NCBI Protein Information
insulin-like growth factor-binding protein 6

UniProt Comments for IGFBP6

IGFBP6: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Protein type: Cell cycle regulation; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: extracellular region; extracellular space; Golgi apparatus

Molecular Function: insulin-like growth factor I binding; insulin-like growth factor II binding; receptor binding

Biological Process: cellular protein metabolic process; negative regulation of cell proliferation; regulation of cell growth; regulation of insulin-like growth factor receptor signaling pathway; signal transduction
Show more

Research Articles on IGFBP6

1. We found that IGFBP6 and SATB2 were significantly down-regulated in HIV-infected CEM*174 cells and 3 different cohorts of HIV/AIDS patients while their promoters were predominantly hyper-methylated compared with normal controls.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IGFBP6 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram

Diseases associated with anti-IGFBP6 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >4 publications with IGFBP6 and Adenocarcinoma
 Disease Models, Animal Antibodies  >4 publications with IGFBP6 and Disease Models, Animal
 Nervous System Diseases Antibodies  >3 publications with IGFBP6 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >3 publications with IGFBP6 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >3 publications with IGFBP6 and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >3 publications with IGFBP6 and Ovarian Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with IGFBP6 and Cardiovascular Diseases
 Lung Diseases Antibodies  >3 publications with IGFBP6 and Lung Diseases
 Fibrosis Antibodies  >2 publications with IGFBP6 and Fibrosis
 Lung Neoplasms Antibodies  >2 publications with IGFBP6 and Lung Neoplasms

Organs/Tissues associated with anti-IGFBP6 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >7 publications with IGFBP6 and Lung
 Liver Antibodies  >6 publications with IGFBP6 and Liver
 Bone Antibodies  >5 publications with IGFBP6 and Bone
 Connective Tissue Antibodies  >4 publications with IGFBP6 and Connective Tissue
 Prostate Antibodies  >4 publications with IGFBP6 and Prostate
 Vascular Antibodies  >4 publications with IGFBP6 and Vascular
 Mouth Antibodies  >4 publications with IGFBP6 and Mouth
 Brain Antibodies  >3 publications with IGFBP6 and Brain
 Uterus Antibodies  >3 publications with IGFBP6 and Uterus
 Kidney Antibodies  >3 publications with IGFBP6 and Kidney
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