DCDC2 Antibody – Goat Polyclonal

This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013]

DCDC2: May be involved in neuronal migration during development of the cerebral neocortex. Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2); also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6p22.1

Cellular Component: axoneme; cytoplasm; cytoskeleton; nucleus

Molecular Function: protein binding

Biological Process: cell projection organization and biogenesis; cellular defense response; neuron migration; positive regulation of smoothened signaling pathway; regulation of Wnt receptor signaling pathway; sensory perception of sound

Disease: Deafness, Autosomal Recessive 66; Nephronophthisis 19