Arachidonate 5-Lipoxygenase (ALOX5) Antibody – Goat Polyclonal

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

5-LO: arachidonate 5-lipoxygenase. Arachidonic acid promotes its phosphorylation by p38 MAPK-regulated MAPKAP kinases. Upregulated in glioblastoma multiforme and colon, pancreatic and bladder cancer.

Protein type: EC 1.13.11.34; Oxidoreductase; Nuclear envelope; Lipid Metabolism - linoleic acid; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 10q11.2

Cellular Component: cytosol; dendrite; extracellular space; nuclear envelope; nuclear envelope lumen; nuclear matrix; nuclear membrane; sarcolemma

Molecular Function: arachidonate 5-lipoxygenase activity; iron ion binding; protein binding

Biological Process: acute inflammatory response; arachidonic acid metabolic process; leukotriene biosynthetic process; leukotriene metabolic process; leukotriene production during acute inflammatory response; lipoxygenase pathway; positive regulation of vasoconstriction; response to hyperoxia; response to nutrient; sensory perception of pain

Disease: Asthma, Susceptibility To