ING2 Antibody – Goat Polyclonal

This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

ING2: Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). Belongs to the ING family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 4q35.1

Cellular Component: CCAAT-binding factor complex; cytoplasm; Golgi apparatus; nucleoplasm; nucleus; plasma membrane; Sin3 complex

Molecular Function: chromatin binding; DNA binding; methylated histone residue binding; phosphoinositide binding; protein binding; protein complex binding; zinc ion binding

Biological Process: chromatin modification; male germ-line stem cell division; male meiosis I; negative regulation of cell proliferation; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of growth; regulation of transcription, DNA-dependent; signal transduction; sperm motility; spermatid development; spermatogenesis; transcription, DNA-dependent