STX1A Antibody – Goat Polyclonal

This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

STX1A: a type IV membrane protein involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. Three splice variant isoforms have been described.

Protein type: Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: cytosol; integral to membrane; neuron projection; plasma membrane; SNARE complex; synaptic vesicle; voltage-gated potassium channel complex

Molecular Function: chloride channel inhibitor activity; kinase binding; myosin binding; protein binding; SNAP receptor activity; SNARE binding

Biological Process: glutamate secretion; intracellular protein transport; neurotransmitter secretion; positive regulation of calcium ion-dependent exocytosis; positive regulation of catecholamine secretion; regulation of insulin secretion; secretion by cell; synaptic vesicle fusion to presynaptic membrane; vesicle docking