Goat Anti-ACOX2 Polyclonal Antibody – Cat# MBS420551

(0.1ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

ACOX2 Antibody – Goat Polyclonal

Name: ACOX2 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS420551
Price: 450 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420551

MBS420551 is an antibody targeting ACOX2. Also known as Goat anti-ACOX2 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ACOX2, Polyclonal Antibody

Full Product Name

Goat anti-ACOX2 Antibody

Product Gene Name

anti-ACOX2 antibody

Product Synonym Names

Goat Anti-ACOX2 (Human) Antibody; ACOX2; acyl-Coenzyme A oxidase 2, branched chain; BCOX; BRCACOX; BRCOX; THCCox; Peroxisomal branched chain acyl-CoA oxidase; THCA-CoA oxidase; Trihydroxycoprostanoyl-CoA oxidase; ACOX2 antibody; acyl-Coenzyme A oxidase 2; branched chain antibody; BCOX antibody; BRCACOX antibody; BRCOX antibody; THCCox antibody; Peroxisomal branched chain acyl-CoA oxidase antibody; THCA-CoA oxidase antibody; Trihydroxycoprostanoyl-CoA oxidase antibody

Immunogen Sequence

HQSRLRPSDP EAK

Clonality

Polyclonal

Host

Goat

Species Reactivity

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Cow

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Antibody/Peptide Pairs

ACOX2 peptide (MBS426064) is used for blocking the activity of ACOX2 antibody (MBS420551)

Molecular Weight

76,827 Da

OMIM

601641

Immunogen

Peptide with sequence C-HQSRLRPSDPEAK, from the internal region (near the C Terminus) of the protein sequence according to NP_003491.1.

Epitope

Internal region (near the C Terminus)

Note

Please note this antibody was designed using the mouse sequence, which differs by 1 amino acids from the human sequence.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-ACOX2 antibody

Peptide ELISA (EIA), Western Blot (WB)

Application Notes for anti-ACOX2 antibody

Peptide ELISA: Antibody detection limit dilution 1: 32000.

Other Notes

Small volumes of anti-ACOX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ACOX2. It may not necessarily be applicable to this product.

NCBI GI #

4501869

NCBI GeneID

8309

NCBI Accession #

NP_003491.1

UniProt Secondary Accession #

A6NF16; B2R8U5

UniProt Related Accession #

Q99424

GenBank Nucleotide #

NM_003500.3

NCBI Official Full Name

peroxisomal acyl-coenzyme A oxidase 2

NCBI Official Synonym Full Names

acyl-CoA oxidase 2, branched chain

NCBI Official Symbol

ACOX2

NCBI Official Synonym Symbols

BCOX; BRCOX; THCCox; BRCACOX

UniProt Protein Name

Peroxisomal acyl-coenzyme A oxidase 2

UniProt Synonym Protein Names

3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; Trihydroxycoprostanoyl-CoA oxidase; THCA-CoA oxidase; THCCox

Protein Family

Peroxisomal acyl-coenzyme A oxidase

UniProt Gene Name

ACOX2

UniProt Synonym Gene Names

THCA-CoA oxidase; THCCox

UniProt Entry Name

ACOX2_HUMAN

NCBI Protein Information

peroxisomal acyl-coenzyme A oxidase 2

NCBI Summary for ACOX2

The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe mental retardation, and death in children. [provided by RefSeq, Mar 2009]

UniProt Comments for ACOX2

ACOX2: Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids. Belongs to the acyl-CoA oxidase family.

Protein type: EC 1.17.99.3; Lipid Metabolism - primary bile acid biosynthesis; Oxidoreductase

Chromosomal Location of Human Ortholog: 3p14.3

Cellular Component: intracellular membrane-bound organelle; mitochondrion; peroxisomal matrix; peroxisome

Molecular Function: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity; acyl-CoA binding; acyl-CoA dehydrogenase activity; acyl-CoA oxidase activity; electron carrier activity; FAD binding; fatty acid binding; pristanoyl-CoA oxidase activity; receptor binding

Biological Process: bile acid biosynthetic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; fatty acid beta-oxidation using acyl-CoA oxidase; lipid homeostasis

Research Articles on ACOX2

1. Results found an ACOX2 variant present in a subset of human breast cancers and associated with improved outcome ER+ tumors suggesting it as a potential novel therapeutic biomarker in ER+ breast tumors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ACOX2 antibody

Products by Pathway	Pathway Diagram
Beta-oxidation Of Pristanoyl-CoA Pathway antibodies	Beta-oxidation Of Pristanoyl-CoA Pathway Diagram
Bile Acid And Bile Salt Metabolism Pathway antibodies	Bile Acid And Bile Salt Metabolism Pathway Diagram
Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway antibodies	Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway Diagram
Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway antibodies	Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
PPAR Signaling Pathway antibodies	PPAR Signaling Pathway Diagram
PPAR Signaling Pathway antibodies	PPAR Signaling Pathway Diagram
Peroxisomal Lipid Metabolism Pathway antibodies	Peroxisomal Lipid Metabolism Pathway Diagram

Diseases associated with anti-ACOX2 antibody

Disease Name	Pubmed Publications
Fatty Liver Antibodies	>4 publications with ACOX2 and Fatty Liver
Cardiovascular Diseases Antibodies	>3 publications with ACOX2 and Cardiovascular Diseases
Carcinoma, Hepatocellular Antibodies	>2 publications with ACOX2 and Carcinoma, Hepatocellular
Carcinoma Antibodies	>2 publications with ACOX2 and Carcinoma
Disease Models, Animal Antibodies	>2 publications with ACOX2 and Disease Models, Animal
Breast Neoplasms Antibodies	>2 publications with ACOX2 and Breast Neoplasms
Liver Diseases Antibodies	>2 publications with ACOX2 and Liver Diseases
Liver Neoplasms Antibodies	>2 publications with ACOX2 and Liver Neoplasms
Adenocarcinoma Antibodies	>2 publications with ACOX2 and Adenocarcinoma
Hypertension Antibodies	>1 publications with ACOX2 and Hypertension

Organs/Tissues associated with anti-ACOX2 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>6 publications with ACOX2 and Liver
Heart Antibodies	>1 publications with ACOX2 and Heart
Muscle Antibodies	>1 publications with ACOX2 and Muscle
Thyroid Antibodies	>1 publications with ACOX2 and Thyroid
Lung Antibodies	>1 publications with ACOX2 and Lung
Connective Tissue Antibodies	>1 publications with ACOX2 and Connective Tissue
Testis Antibodies	>1 publications with ACOX2 and Testis