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MAP3K7IP3 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420572

MBS420572 is an antibody targeting MAP3K7IP3. Also known as Goat anti-MAP3K7IP3 (aa 274 to 285) Antibody. Reactive in Expected from sequence similarity: Human, Mouse. Host: Goat. More details

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Product Overview

Product Name
MAP3K7IP3, Polyclonal Antibody
Full Product Name
Goat anti-MAP3K7IP3 (aa 274 to 285) Antibody
Product Gene Name
anti-MAP3K7IP3 antibody
Product Synonym Names
Goat Anti-MAP3K7IP3 (aa 59 to 69) Antibody; MAP3K7IP3; mitogen-activated protein kinase kinase kinase 7 interacting protein 3; MGC45404; NAP1; TAB3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NF-kappa-B-activating protein 1; NFkB activating protein 1; TAK1 binding prote; MAP3K7IP3 antibody; mitogen-activated protein kinase kinase kinase 7 interacting protein 3 antibody; MGC45404 antibody; NAP1 antibody; TAB3 antibody; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 antibody; NF-kappa-B-activating protein 1 antibody; NFkB activating protein 1 antibody; TAK1 bindi antibody; MAP3K7IP3 (aa 274 to 285)
Immunogen Sequence
NYQPSQYSPK QQ
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Mouse
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
MAP3K7IP3 peptide (MBS428027) is used for blocking the activity of MAP3K7IP3 antibody (MBS420572)
Molecular Weight
75,599 Da
OMIM
300480
Immunogen
Peptide with sequence C-NYQPSQYSPKQQ, from the internal region of the protein sequence according to NP_690000.2.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-MAP3K7IP3 antibody
Peptide ELISA (EIA)
Application Notes for anti-MAP3K7IP3 antibody
Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Preliminary experiments gave an approx 48kDa band in Human Kidney lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 78.7kDa according to NP_690000.2. The 48kDa band was successfully blocked by incubation with the immunizing peptide.

Other Notes

Small volumes of anti-MAP3K7IP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MAP3K7IP3. It may not necessarily be applicable to this product.

NCBI GI #
98991767
NCBI GeneID
257397
NCBI Accession #
NP_690000.2
UniProt Secondary Accession #
Q6VQR0; A6NDD9
UniProt Related Accession #
Q8N5C8
GenBank Nucleotide #
NM_152787.3
NCBI Official Full Name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
NCBI Official Synonym Full Names
TGF-beta activated kinase 1/MAP3K7 binding protein 3
NCBI Official Symbol
TAB3
NCBI Official Synonym Symbols
NAP1; MAP3K7IP3
UniProt Protein Name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
UniProt Synonym Protein Names
Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NF-kappa-B-activating protein 1; TAK1-binding protein 3; TAB-3; TGF-beta-activated kinase 1-binding protein 3
Protein Family
Mitogen-activated protein kinase kinase kinase 7-interacting protein
UniProt Gene Name
TAB3
UniProt Synonym Gene Names
MAP3K7IP3; TAB-3
UniProt Entry Name
TAB3_HUMAN
NCBI Protein Information
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

NCBI Summary for MAP3K7IP3

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
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UniProt Comments for MAP3K7IP3

TAB3: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: Xp21.2

Cellular Component: cytoplasm; cytosol; endosome membrane; nucleoplasm; plasma membrane

Molecular Function: protein binding; zinc ion binding

Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; I-kappaB kinase/NF-kappaB cascade; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; negative regulation of autophagy; stimulatory C-type lectin receptor signaling pathway
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Research Articles on MAP3K7IP3

1. miR-30a in MSCs may participate in the immune dysregulation of the maternal-fetal interface during PE

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MAP3K7IP3 antibody

 Reference Product  PubMed Publications
 TAB2 antibody  >34 publications with MAP3K7IP3 and TAB2
 TAB1 antibody  >13 publications with MAP3K7IP3 and TAB1
 TRAF6 antibody  >7 publications with MAP3K7IP3 and TRAF6
 IKBKB antibody  >6 publications with MAP3K7IP3 and IKBKB
 IRAK2 antibody  >3 publications with MAP3K7IP3 and IRAK2
 MAP3K7 antibody  >2 publications with MAP3K7IP3 and MAP3K7
 CHUK antibody  >1 publications with MAP3K7IP3 and CHUK

Pathways associated with anti-MAP3K7IP3 antibody

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 C-type Lectin Receptors (CLRs) Pathway antibodies  C-type Lectin Receptors (CLRs) Pathway Diagram
 CLEC7A (Dectin-1) Signaling Pathway antibodies  CLEC7A (Dectin-1) Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Death Receptor Signalling Pathway antibodies  Death Receptor Signalling Pathway Diagram
 FCERI Mediated NF-kB Activation Pathway antibodies  FCERI Mediated NF-kB Activation Pathway Diagram
 Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies  Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram
 IRAK2 Mediated Activation Of TAK1 Complex Pathway antibodies  IRAK2 Mediated Activation Of TAK1 Complex Pathway Diagram
 IRAK2 Mediated Activation Of TAK1 Complex Upon TLR7/8 Or 9 Stimulation Pathway antibodies  IRAK2 Mediated Activation Of TAK1 Complex Upon TLR7/8 Or 9 Stimulation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram

Diseases associated with anti-MAP3K7IP3 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >15 publications with MAP3K7IP3 and Necrosis
 Inflammation Antibodies  >9 publications with MAP3K7IP3 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >4 publications with MAP3K7IP3 and Carcinoma, Hepatocellular
 Immune System Diseases Antibodies  >4 publications with MAP3K7IP3 and Immune System Diseases
 Liver Diseases Antibodies  >4 publications with MAP3K7IP3 and Liver Diseases
 Liver Neoplasms Antibodies  >4 publications with MAP3K7IP3 and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with MAP3K7IP3 and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >1 publications with MAP3K7IP3 and Breast Neoplasms
 Kidney Diseases Antibodies  >1 publications with MAP3K7IP3 and Kidney Diseases
 Disease Models, Animal Antibodies  >1 publications with MAP3K7IP3 and Disease Models, Animal

Organs/Tissues associated with anti-MAP3K7IP3 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with MAP3K7IP3 and Liver
 Blood Antibodies  >3 publications with MAP3K7IP3 and Blood
 Intestine Antibodies  >2 publications with MAP3K7IP3 and Intestine
 Kidney Antibodies  >2 publications with MAP3K7IP3 and Kidney
 Lung Antibodies  >1 publications with MAP3K7IP3 and Lung
 Embryonic Tissue Antibodies  >1 publications with MAP3K7IP3 and Embryonic Tissue
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