MLL4 Antibody – Goat Polyclonal

This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008]

MLL2: may be a transcriptional regulator. Contains 3 A.T hook DNA-binding domains. Two alternatively spliced isoforms have been described.

Protein type: EC 2.1.1.43; Methyltransferase, protein lysine; Transcription factor; Methyltransferase; DNA-binding

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: histone methyltransferase complex; nucleoplasm; nucleus

Molecular Function: DNA binding; histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; protein binding; transcription factor activity; zinc ion binding

Biological Process: chromatin-mediated maintenance of transcription; gene silencing; histone H3-K4 methylation; memory; oocyte differentiation; ovarian follicle development; ovulation; regulation of histone H3-K4 methylation; transcription, DNA-dependent