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ATF7 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420588

MBS420588 is an antibody targeting ATF7. Also known as Goat anti-ATF7 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Rat, Dog, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ATF7, Polyclonal Antibody
Full Product Name
Goat anti-ATF7 Antibody
Product Gene Name
anti-ATF7 antibody
Product Synonym Names
ATF7; ATFA; activating transcription factor 7; MGC57182; ATF7 antibody; ATFA antibody; activating transcription factor 7 antibody; MGC57182 antibody
Immunogen Sequence
HVIMTPQSQS AGR
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Rat, Dog, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
ATF7 peptide (MBS426048) is used for blocking the activity of ATF7 antibody (MBS420588)
Molecular Weight
51,757 Da
OMIM
606371
Immunogen
Peptide with sequence C-HVIMTPQSQSAGR, from the C Terminus of the protein sequence according to NP_001123531.1; NP_006847.1; NP_001123532.1.
Epitope
C Terminus
Note
This antibody is expected to recognise all three reported isoforms (NP_001123531.1, NP_006847.1 and NP_001123532.1).
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-ATF7 antibody
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ATF7 antibody
Peptide ELISA: Antibody detection limit dilution 1: 16000.
Immunohistochemistry: In paraffin embedded Human Testis shows staining of select spermatocytes in Human Testis. Recommended concentration, 3-5ug/ml.
Western Blot: Approx 35kDa band seen in HeLa cell lysates. Recommended for use at 0.5-2ug/ml. Please note the band size is in agreement with previous experimental data (J Biol Chem 2001 Apr 27;276(17): 13718-26).

Western Blot (WB) of anti-ATF7 antibody

Staining (0.5ug/ml) of HeLa lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Goat Anti-ATF7 Polyclonal Antibody – Cat# MBS420588

Immunohistochemistry (IHC) of anti-ATF7 antibody

(3.8ug/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Goat Anti-ATF7 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS420588

Other Notes

Small volumes of anti-ATF7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ATF7. It may not necessarily be applicable to this product.

NCBI GI #
194239640
NCBI GeneID
11016
NCBI Accession #
NP_001123531.1
NCBI Related Accession #
NP_006847.1; NP_001123532.1
UniProt Secondary Accession #
Q13814; Q8IVR8; Q9UD83; A5D6Y4; B2RMP1; B4DQL4
UniProt Related Accession #
P17544
GenBank Nucleotide #
NM_001130059.1
NCBI Official Synonym Full Names
activating transcription factor 7
NCBI Official Symbol
ATF7
NCBI Official Synonym Symbols
ATFA
UniProt Protein Name
Cyclic AMP-dependent transcription factor ATF-7
UniProt Synonym Protein Names
Activating transcription factor 7; Transcription factor ATF-A
Protein Family
Cyclic AMP-dependent transcription factor
UniProt Gene Name
ATF7
UniProt Synonym Gene Names
ATFA; cAMP-dependent transcription factor ATF-7
UniProt Entry Name
ATF7_HUMAN
NCBI Protein Information
cyclic AMP-dependent transcription factor ATF-7

UniProt Comments for ATF7

ATF7: Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]- 3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Belongs to the bZIP family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q13

Molecular Function: enzyme binding; mitogen-activated protein kinase binding; protein binding; transcription factor binding

Biological Process: regulation of transcription, DNA-dependent
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Research Articles on ATF7

1. It is negatively related between ATF7 expression and pathological stage and positive correlation with OS and PFS in CRC. ATF7 expression is a favorable factor for survival of patients with CRC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ATF7 antibody

 Reference Product  PubMed Publications
 TAF12 antibody  >5 publications with ATF7 and TAF12
 FOS antibody  >4 publications with ATF7 and FOS
 PTP4A1 antibody  >1 publications with ATF7 and PTP4A1
 MAPK8 antibody  >1 publications with ATF7 and MAPK8

Pathways associated with anti-ATF7 antibody

 Products by Pathway  Pathway Diagram
 Regulation Of Retinoblastoma Protein Pathway antibodies  Regulation Of Retinoblastoma Protein Pathway Diagram

Diseases associated with anti-ATF7 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >4 publications with ATF7 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >2 publications with ATF7 and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >1 publications with ATF7 and Neoplasm Metastasis
 Brain Diseases Antibodies  >1 publications with ATF7 and Brain Diseases
 Nervous System Diseases Antibodies  >1 publications with ATF7 and Nervous System Diseases

Organs/Tissues associated with anti-ATF7 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >3 publications with ATF7 and Bone Marrow
 Bone Antibodies  >3 publications with ATF7 and Bone
 Blood Antibodies  >3 publications with ATF7 and Blood
 Lung Antibodies  >1 publications with ATF7 and Lung
 Lymph Node Antibodies  >1 publications with ATF7 and Lymph Node
 Liver Antibodies  >1 publications with ATF7 and Liver
 Heart Antibodies  >1 publications with ATF7 and Heart
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