Neuroligin 1 (NLGN1) Antibody – Goat Polyclonal

NLGN1: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q26.31

Cellular Component: cell junction; cell surface; cytosol; dendrite; dendritic shaft; dendritic spine; external side of plasma membrane; extracellular space; filopodium tip; Golgi apparatus; integral to plasma membrane; N-methyl-D-aspartate selective glutamate receptor complex; plasma membrane; postsynaptic density; postsynaptic membrane; synapse

Molecular Function: cell adhesion molecule binding; neurexin binding; PDZ domain binding; protein dimerization activity; receptor activity

Biological Process: calcium-dependent cell-cell adhesion; cytoskeletal matrix organization at active zone; establishment of protein localization; heterophilic cell adhesion; nervous system development; neurite development; neurological control of breathing; neuron adhesion; positive regulation of filopodium formation; positive regulation of synaptic transmission, GABAergic; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; protein heterotetramerization; protein homooligomerization; protein targeting; regulation of neuron differentiation; rhythmic process; synaptic vesicle targeting; synaptogenesis