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SORBS1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420677

MBS420677 is an antibody targeting SORBS1. Also known as Goat anti-SORBS1/ponsin (internal) Antibody. Reactive in Expected from sequence similarity: Human. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SORBS1/ponsin, Polyclonal Antibody
Full Product Name
Goat anti-SORBS1/ponsin (internal) Antibody
Product Gene Name
anti-SORBS1 antibody
Product Synonym Names
Goat Anti-SORBS1/ponsin (internal region) Antibody; SORBS1; sorbin and SH3 domain containing 1; CAP; DKFZp451C066; DKFZp586P1422; FLAF2; FLJ12406; KIAA1296; R85FL; SH3D5; SH3P12; SORB1; Fas-ligand associated factor 2; SH3-domain protein 5; SH3-domain protein 5 (ponsin); c-Cbl associated protein; ponsin; SORBS1 antibody; sorbin and SH3 domain containing 1 antibody; CAP antibody; DKFZp451C066 antibody; DKFZp586P1422 antibody; FLAF2 antibody; FLJ12406 antibody; KIAA1296 antibody; R85FL antibody; SH3D5 antibody; SH3P12 antibody; SORB1 antibody; Fas-ligand associated factor 2 antibody; SH3-domain protein 5 antibody; SH3-domain protein 5 (ponsin) antibody; c-Cbl associated protein antibody; ponsin antibody; Ponsin; SORBS1 / ponsin (internal)
Immunogen Sequence
SPKSEDDDSD LYSP
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
SORBS1 / ponsin peptide (MBS428526) is used for blocking the activity of SORBS1/ponsin antibody (MBS420677)
Molecular Weight
143,741 Da
OMIM
605264
Immunogen
Peptide with sequence C-SPKSEDDDSDLYSP, from the internal region of the protein sequence according to NP_006425.2; NP_056200.1; NP_001030126.1; NP_001030127.1; NP_001030128.1; NP_079267.1; NP_001030129.1.
Epitope
Internal region
Note
This antibody is expected to recognise all 7 reported isoforms (NP_006425.2, NP_056200.1, NP_001030126.1, NP_001030127.1, NP_001030128.1, NP_079267.1 and NP_001030129.1).
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-SORBS1 antibody
Peptide ELISA (EIA)
Application Notes for anti-SORBS1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 2000.
Western Blot: Preliminary experiments in Human Adipose, Heart, Kidney, Liver and Muscle lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).

Other Notes

Small volumes of anti-SORBS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SORBS1. It may not necessarily be applicable to this product.

NCBI GI #
78000160
NCBI GeneID
10580
NCBI Accession #
NP_006425.2
NCBI Related Accession #
NP_056200.1; NP_001030126.1; NP_001030127.1; NP_001030128.1; NP_079267.1; NP_001030129.1
UniProt Secondary Accession #
O43857; Q5T923; Q5T924; Q5T927; Q5T928; A0AED4; A6NEK3; A6NID8; A6NJS4; A7MD40; D3DR42
UniProt Related Accession #
Q9BX66
GenBank Nucleotide #
NM_006434.2
NCBI Official Full Name
sorbin and SH3 domain-containing protein 1 isoform 1
NCBI Official Synonym Full Names
sorbin and SH3 domain containing 1
NCBI Official Symbol
SORBS1
NCBI Official Synonym Symbols
CAP; FLAF2; R85FL; SH3D5; SORB1; SH3P12
UniProt Protein Name
Sorbin and SH3 domain-containing protein 1
UniProt Synonym Protein Names
Ponsin; SH3 domain protein 5; SH3P12; c-Cbl-associated protein; CAP
Protein Family
Sorbin and SH3 domain-containing protein
UniProt Gene Name
SORBS1
UniProt Synonym Gene Names
CAP
UniProt Entry Name
SRBS1_HUMAN
NCBI Protein Information
sorbin and SH3 domain-containing protein 1

NCBI Summary for SORBS1

This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

UniProt Comments for SORBS1

SORBS1: Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions. 12 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q23.33

Cellular Component: cell-cell adherens junction; cell-substrate adherens junction; centrosome; cytoplasm; cytosol; focal adhesion; lipid raft; nucleoplasm; nucleus; plasma membrane; stress fiber; zonula adherens

Molecular Function: actin binding; cytoskeletal protein binding; insulin receptor binding; protein binding; SH3/SH2 adaptor activity

Biological Process: cell-matrix adhesion; cellular response to insulin stimulus; focal adhesion formation; glucose transport; insulin receptor signaling pathway; muscle contraction; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of lipid biosynthetic process; stress fiber formation
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Research Articles on SORBS1

1. data suggest that SORBS1 might be a gene involved in diabetic nephropathy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SORBS1 antibody

 Reference Product  PubMed Publications
 CBL antibody  >9 publications with SORBS1 and CBL

Pathways associated with anti-SORBS1 antibody

 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Insulin Pathway antibodies  Insulin Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram

Diseases associated with anti-SORBS1 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >7 publications with SORBS1 and Cardiovascular Diseases
 Inflammation Antibodies  >4 publications with SORBS1 and Inflammation
 Heart Diseases Antibodies  >3 publications with SORBS1 and Heart Diseases
 Nervous System Diseases Antibodies  >3 publications with SORBS1 and Nervous System Diseases
 Hypertrophy Antibodies  >2 publications with SORBS1 and Hypertrophy
 Cardiomegaly Antibodies  >2 publications with SORBS1 and Cardiomegaly
 Skin Diseases Antibodies  >2 publications with SORBS1 and Skin Diseases
 Hypertension Antibodies  >2 publications with SORBS1 and Hypertension
 Disease Models, Animal Antibodies  >2 publications with SORBS1 and Disease Models, Animal
 Liver Neoplasms Antibodies  >1 publications with SORBS1 and Liver Neoplasms

Organs/Tissues associated with anti-SORBS1 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >10 publications with SORBS1 and Muscle
 Adipose Tissue Antibodies  >9 publications with SORBS1 and Adipose Tissue
 Connective Tissue Antibodies  >6 publications with SORBS1 and Connective Tissue
 Heart Antibodies  >5 publications with SORBS1 and Heart
 Liver Antibodies  >3 publications with SORBS1 and Liver
 Embryonic Tissue Antibodies  >2 publications with SORBS1 and Embryonic Tissue
 Bone Antibodies  >2 publications with SORBS1 and Bone
 Ovary Antibodies  >2 publications with SORBS1 and Ovary
 Prostate Antibodies  >2 publications with SORBS1 and Prostate
 Brain Antibodies  >2 publications with SORBS1 and Brain
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