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Tissue Factor Pathway Inhibitor (TFPI) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420689

MBS420689 is an antibody targeting TFPI. Also known as Goat anti-Tissue Factor Pathway Inhibitor Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tissue Factor Pathway Inhibitor (TFPI), Polyclonal Antibody
Full Product Name
Goat anti-Tissue Factor Pathway Inhibitor Antibody
Product Gene Name
anti-TFPI antibody
Product Synonym Names
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor); TFPI; EPI; LACI; TFI; TFPI1; OTTHUMP00000163472; OTTHUMP00000205431; anti-convertin; extrinsic pathway inhibitor; lipoprotein-associated coagulation inhibitor; tissue factor p; tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) antibody; TFPI antibody; EPI antibody; LACI antibody; TFI antibody; TFPI1 antibody; OTTHUMP00000163472 antibody; OTTHUMP00000205431 antibody; anti-convertin antibody; extrinsic pathway inhibitor antibody; lipoprotein-associated coagulation inhibitor antibody; tissue factor pathway inhibitor antibody; Tissue Factor Pathway Inhibitor; Tissue Factor Pathway Inhibitor
Immunogen Sequence
VKIAYEEIFV KNM
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
Tissue Factor Pathway Inhibitor peptide (MBS426836) is used for blocking the activity of Tissue Factor Pathway Inhibitor antibody (MBS420689)
Molecular Weight
28,653 Da
OMIM
152310
Immunogen
Peptide with sequence C-VKIAYEEIFVKNM, from the C Terminus of the protein sequence according to NP_006278.1.
Epitope
C Terminus
Note
This antibody is expected to recognize isoform a (NP_006278.1) only.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-TFPI antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-TFPI antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 50kDa band observed in lysates of cell lines HepG2 and HeLa (calculated MW of 35. 0kDa according to NP_006278.1). In transfected HEK293 transiently expressing TFPI bands of approx.38kDa to 45kDa are observed. These bands are not observed in the non-transfected HEK293. Recommended concentration: 0.3-1ug/ml.

Western Blot (WB) of anti-TFPI antibody

HEK293 overexpressing TFPI (RC219033) and probed (mock transfection in first lane), tested by Origene.
Goat Anti-TFPI Polyclonal Antibody – Cat# MBS420689

Western Blot (WB) of anti-TFPI antibody

Staining (0.3ug/ml) of Hela lysate (RIPA buffer, 35ug total protein cells per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Goat Anti-TFPI Polyclonal Antibody, Western Blot (WB) – Cat# MBS420689

Other Notes

Small volumes of anti-TFPI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TFPI. It may not necessarily be applicable to this product.

NCBI GI #
5454114
NCBI GeneID
7035
NCBI Accession #
NP_006278.1
UniProt Secondary Accession #
O95103; Q53TS4
UniProt Related Accession #
P10646
GenBank Nucleotide #
NM_006287.4
NCBI Official Full Name
tissue factor pathway inhibitor isoform a
NCBI Official Synonym Full Names
tissue factor pathway inhibitor
NCBI Official Symbol
TFPI
NCBI Official Synonym Symbols
EPI; TFI; LACI; TFPI1
UniProt Protein Name
Tissue factor pathway inhibitor
UniProt Synonym Protein Names
Extrinsic pathway inhibitor; EPI; Lipoprotein-associated coagulation inhibitor; LACI
Protein Family
Tissue factor pathway inhibitor
UniProt Gene Name
TFPI
UniProt Synonym Gene Names
LACI; TFPI1; TFPI; EPI; LACI
UniProt Entry Name
TFPI1_HUMAN
NCBI Protein Information
tissue factor pathway inhibitor

NCBI Summary for TFPI

This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008]
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UniProt Comments for TFPI

TFPI: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor; Secreted, signal peptide; Inhibitor; Secreted

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: cell surface; endoplasmic reticulum; extracellular region; extracellular space; plasma membrane

Molecular Function: endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity

Biological Process: blood coagulation; blood coagulation, extrinsic pathway
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Research Articles on TFPI

1. coagulation system, TFPI play an important role in the pathogenesis of CRSwNP.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TFPI antibody

 Reference Product  PubMed Publications
 F10 antibody  >5 publications with TFPI and F10
 SON antibody  >2 publications with TFPI and SON
 SDC4 antibody  >2 publications with TFPI and SDC4

Pathways associated with anti-TFPI antibody

 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Extrinsic Pathway Of Fibrin Clot Formation antibodies  Extrinsic Pathway Of Fibrin Clot Formation Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Syndecan-4-mediated Signaling Events Pathway antibodies  Syndecan-4-mediated Signaling Events Pathway Diagram

Diseases associated with anti-TFPI antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >557 publications with TFPI and Cardiovascular Diseases
 Inflammation Antibodies  >214 publications with TFPI and Inflammation
 Heart Diseases Antibodies  >140 publications with TFPI and Heart Diseases
 Venous Thrombosis Antibodies  >139 publications with TFPI and Venous Thrombosis
 Disease Models, Animal Antibodies  >86 publications with TFPI and Disease Models, Animal
 Necrosis Antibodies  >84 publications with TFPI and Necrosis
 Myocardial Infarction Antibodies  >69 publications with TFPI and Myocardial Infarction
 Kidney Diseases Antibodies  >59 publications with TFPI and Kidney Diseases
 Neoplasm Metastasis Antibodies  >40 publications with TFPI and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >38 publications with TFPI and Adenocarcinoma

Organs/Tissues associated with anti-TFPI antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1340 publications with TFPI and Blood
 Vascular Antibodies  >563 publications with TFPI and Vascular
 Embryonic Tissue Antibodies  >105 publications with TFPI and Embryonic Tissue
 Muscle Antibodies  >100 publications with TFPI and Muscle
 Lung Antibodies  >98 publications with TFPI and Lung
 Heart Antibodies  >92 publications with TFPI and Heart
 Liver Antibodies  >84 publications with TFPI and Liver
 Kidney Antibodies  >82 publications with TFPI and Kidney
 Placenta Antibodies  >50 publications with TFPI and Placenta
 Umbilical Cord Antibodies  >47 publications with TFPI and Umbilical Cord
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