SART1 Antibody – Goat Polyclonal

This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]

SART1: May play a role in mRNA splicing. May also bind to DNA. Belongs to the SNU66/SART1 family. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Apoptosis; Spliceosome; RNA processing; RNA splicing

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: Cajal body; cytoplasm; cytosol; Golgi apparatus; nucleoplasm; U4/U6 x U5 tri-snRNP complex

Molecular Function: protein binding

Biological Process: cell cycle arrest; maturation of 5S rRNA; nuclear mRNA cis splicing, via U2-type spliceosome; nuclear mRNA splicing, via spliceosome; positive regulation of cytotoxic T cell differentiation; spliceosomal snRNP biogenesis