Dopamine Receptor D4/DRD4 (DRD4) Antibody – Goat Polyclonal

This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]

DRD4: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: cell cortex; cell soma; dendritic spine; integral to plasma membrane; membrane; plasma membrane; terminal button; vesicle membrane

Molecular Function: dopamine binding; dopamine D1 receptor-like receptor activity; dopamine D2 receptor-like receptor activity; dopamine receptor activity; drug binding; identical protein binding; potassium channel regulator activity; protein binding; SH3 domain binding

Biological Process: activation of MAPK activity; adult locomotory behavior; arachidonic acid secretion; behavioral fear response; behavioral response to cocaine; behavioral response to ethanol; cellular calcium ion homeostasis; circadian rhythm; dopamine metabolic process; dopamine receptor signaling pathway; dopamine receptor, adenylate cyclase inhibiting pathway; fear response; negative regulation of adenylate cyclase activity; negative regulation of cAMP biosynthetic process; negative regulation of protein secretion; olfactory learning; photoperiodism; positive regulation of dopamine uptake; positive regulation of kinase activity; positive regulation of sodium:hydrogen antiporter activity; regulation of calcium-mediated signaling; regulation of circadian rhythm; regulation of dopamine metabolic process; regulation of inhibitory postsynaptic membrane potential; regulation of neurotransmitter secretion; response to amphetamine; response to steroid hormone stimulus; retina development in camera-type eye; short-term memory; social behavior; synaptic transmission, dopaminergic

Disease: Attention Deficit-hyperactivity Disorder; Novelty Seeking Personality Trait