VANGL2 Antibody – Goat

The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]

VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family.

Protein type: Membrane protein, multi-pass; Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q22-q23

Cellular Component: apical plasma membrane; basolateral plasma membrane; ER to Golgi transport vesicle; integral to membrane; intercellular junction; lateral plasma membrane; plasma membrane; stress fiber

Molecular Function: protein binding

Biological Process: anterior/posterior pattern formation; apical protein localization; convergent extension involved in axis elongation; convergent extension involved in neural plate elongation; digestive tract morphogenesis; establishment and/or maintenance of epithelial cell polarity; establishment of body hair orientation; establishment of planar polarity; glomerulus development; hair follicle development; heart looping; heparan sulfate proteoglycan biosynthetic process; inner ear receptor stereocilium organization and biogenesis; neural tube closure; positive regulation of JNK activity; regulation of actin cytoskeleton organization and biogenesis; regulation of Wnt receptor signaling pathway; Rho protein signal transduction; sensory cilium biogenesis; somatic stem cell division; somatic stem cell maintenance; wound healing

Disease: Neural Tube Defects