NMDA Receptor 1/GRIN1 (GRIN1) Antibody – Goat

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

NMDAR1: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Three alternatively-spliced isoforms have been described.

Protein type: Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass; Channel, calcium

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: cell junction; cell soma; cell surface; dendrite; dendritic spine; endoplasmic reticulum; excitatory synapse; integral to plasma membrane; N-methyl-D-aspartate selective glutamate receptor complex; neuron projection; plasma membrane; postsynaptic density; postsynaptic membrane; synapse; synaptic vesicle; terminal button

Molecular Function: calcium channel activity; calcium ion binding; calmodulin binding; enzyme binding; extracellular-glutamate-gated ion channel activity; glutamate binding; glutamate receptor binding; glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; neurotransmitter binding; protein binding; protein heterodimerization activity; Ras guanyl-nucleotide exchange factor activity; voltage-gated cation channel activity

Biological Process: adult locomotory behavior; calcium ion homeostasis; cation transport; cellular calcium ion homeostasis; cerebral cortex development; conditioned taste aversion; ephrin receptor signaling pathway; ionotropic glutamate receptor signaling pathway; long-term memory; male mating behavior; MAPKKK cascade; negative regulation of neuron apoptosis; olfactory learning; pons maturation; positive regulation of apoptosis; positive regulation of GTPase activity; positive regulation of transcription from RNA polymerase II promoter; prepulse inhibition; propylene metabolic process; protein tetramerization; regulation of axonogenesis; regulation of dendrite morphogenesis; regulation of excitatory postsynaptic membrane potential; regulation of long-term neuronal synaptic plasticity; regulation of membrane potential; regulation of respiratory gaseous exchange; regulation of synaptogenesis; respiratory gaseous exchange; response to amphetamine; response to calcium ion; response to ethanol; response to morphine; rhythmic process; sensory perception of pain; social behavior; suckling behavior; synaptic transmission; synaptic transmission, glutamatergic; visual learning

Disease: Mental Retardation, Autosomal Dominant 8