Goat Anti-RXRG Polyclonal Antibody – Cat# MBS420893

(1ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

RXR Gamma (RXRG) Antibody – Goat Polyclonal

Name: RXRG Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS420893
Price: 450 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420893

MBS420893 is an antibody targeting RXRG. Also known as Goat anti-RXR gamma Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RXR gamma (RXRG), Polyclonal Antibody

Full Product Name

Goat anti-RXR gamma Antibody

Product Gene Name

anti-RXRG antibody

Product Synonym Gene Name

RXR gamma

Product Synonym Names

RXRG; RXRC; NR2B3; retinoid X receptor, gamma; RXRG antibody; RXRC antibody; NR2B3 antibody; retinoid X receptor; gamma antibody; RXR gamma

Immunogen Sequence

RQRSRERAES EAEC

Clonality

Polyclonal

Host

Goat

Species Reactivity

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Antibody/Peptide Pairs

RXR gamma peptide (MBS426472) is used for blocking the activity of RXR gamma antibody (MBS420893)

Molecular Weight

50,871 Da

OMIM

180247

Immunogen

Peptide with sequence RQRSRERAESEAEC, from the internal region of the protein sequence according to NP_008848.1.

Epitope

Internal region

Note

This antibody is expected to recognise an epitope corresponding to aa 213-226 of human RXR gamma protein (hinge region) and does not cross-react with either RXR alpha or beta.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-RXRG antibody

Peptide ELISA (EIA), Western Blot (WB)

Application Notes for anti-RXRG antibody

Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx 65kDa band observed in lysates of cell line HeLa (calculated MW of 50.9kDa according to NP_008848.1). Recommended concentration: 1-3ug/ml.

Other Notes

Small volumes of anti-RXRG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RXRG. It may not necessarily be applicable to this product.

NCBI GI #

5902068

NCBI GeneID

6258

NCBI Accession #

NP_008848.1

UniProt Secondary Accession #

Q6IBU7; A6NIP1

UniProt Related Accession #

P48443

GenBank Nucleotide #

NM_006917.4

NCBI Official Full Name

retinoic acid receptor RXR-gamma isoform a

NCBI Official Synonym Full Names

retinoid X receptor gamma

NCBI Official Symbol

RXRG

NCBI Official Synonym Symbols

RXRC; NR2B3

UniProt Protein Name

Retinoic acid receptor RXR-gamma

UniProt Synonym Protein Names

Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma

Protein Family

Retinoic acid receptor

UniProt Gene Name

RXRG

UniProt Synonym Gene Names

NR2B3

UniProt Entry Name

RXRG_HUMAN

NCBI Protein Information

retinoic acid receptor RXR-gamma

NCBI Summary for RXRG

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

UniProt Comments for RXRG

RXRG: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Belongs to the nuclear hormone receptor family. NR2 subfamily.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 1q22-q23

Cellular Component: nucleoplasm

Molecular Function: protein binding; retinoid-X receptor activity; steroid hormone receptor activity; zinc ion binding

Biological Process: protein homotetramerization; retinoic acid receptor signaling pathway; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter

Research Articles on RXRG

1. Data show that some rexinoids display selective coactivator (CoA) recruitment by the retinoid X receptors (RXRs) homodimer and by the heterodimers nuclear receptor Nur77/RXR and Nurr1/RXR.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RXRG antibody

Reference Product	PubMed Publications
VDR antibody	>7 publications with RXRG and VDR
PPARG antibody	>5 publications with RXRG and PPARG
RARB antibody	>4 publications with RXRG and RARB
RARG antibody	>3 publications with RXRG and RARG
RARA antibody	>2 publications with RXRG and RARA
THRA antibody	>1 publications with RXRG and THRA
THRB antibody	>1 publications with RXRG and THRB

Pathways associated with anti-RXRG antibody

Products by Pathway	Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Non-small Cell Lung Cancer Pathway antibodies	Non-small Cell Lung Cancer Pathway Diagram
Non-small Cell Lung Cancer Pathway antibodies	Non-small Cell Lung Cancer Pathway Diagram
Nuclear Receptor Transcription Pathway antibodies	Nuclear Receptor Transcription Pathway Diagram
Nuclear Receptors Pathway antibodies	Nuclear Receptors Pathway Diagram
PPAR Signaling Pathway antibodies	PPAR Signaling Pathway Diagram

Diseases associated with anti-RXRG antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>6 publications with RXRG and Inflammation
Congenital Abnormalities Antibodies	>3 publications with RXRG and Congenital Abnormalities
Disease Models, Animal Antibodies	>2 publications with RXRG and Disease Models, Animal
Insulin Resistance Antibodies	>1 publications with RXRG and Insulin Resistance
Lung Neoplasms Antibodies	>1 publications with RXRG and Lung Neoplasms
Lung Diseases Antibodies	>1 publications with RXRG and Lung Diseases
Liver Neoplasms Antibodies	>1 publications with RXRG and Liver Neoplasms
Kidney Diseases Antibodies	>1 publications with RXRG and Kidney Diseases
Liver Diseases Antibodies	>1 publications with RXRG and Liver Diseases
Fatty Liver Antibodies	>1 publications with RXRG and Fatty Liver

Organs/Tissues associated with anti-RXRG antibody

Organ/Tissue Name	Pubmed Publications
Thyroid Antibodies	>9 publications with RXRG and Thyroid
Muscle Antibodies	>3 publications with RXRG and Muscle
Heart Antibodies	>3 publications with RXRG and Heart
Brain Antibodies	>3 publications with RXRG and Brain
Embryonic Tissue Antibodies	>2 publications with RXRG and Embryonic Tissue
Uterus Antibodies	>2 publications with RXRG and Uterus
Testis Antibodies	>1 publications with RXRG and Testis
Skin Antibodies	>1 publications with RXRG and Skin
Lung Antibodies	>1 publications with RXRG and Lung
Eye Antibodies	>1 publications with RXRG and Eye