Goat Anti-FXR1 Polyclonal Antibody – Cat# MBS420898

(0.2ug/ml) staining of NIH/3T3 cell lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

FXR1 Antibody – Goat Polyclonal

Name: FXR1 Antibody; Polyclonal; Goat; Mouse/Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS420898
Price: 450 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420898

MBS420898 is an antibody targeting FXR1. Also known as Goat anti-FXR1 Antibody. Reactive in Tested: Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FXR1, Polyclonal Antibody

Full Product Name

Goat anti-FXR1 Antibody

Product Gene Name

anti-FXR1 antibody

Product Synonym Names

FXR1; fragile X mental retardation, autosomal homolog 1; fragile X mental retardation-related protein 1; FXR1 antibody; fragile X mental retardation; autosomal homolog 1 antibody; fragile X mental retardation-related protein 1 antibody

Immunogen Sequence

RIEGDNENKL PRED

Clonality

Polyclonal

Host

Goat

Species Reactivity

Tested: Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Antibody/Peptide Pairs

FXR1 peptide (MBS426978) is used for blocking the activity of FXR1 antibody (MBS420898)

Molecular Weight

59,920 Da

OMIM

600819

Immunogen

Peptide with sequence C-RIEGDNENKLPRED, from the internal region of the protein sequence according to NP_005078.2; NP_001013456.1; NP_001013457.1.

Epitope

Internal region

Note

This antibody is expected to recognise all reported isoforms (NP_005078.2, NP_001013456.1 and NP_001013457.1).

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-FXR1 antibody

Peptide ELISA (EIA), Western Blot (WB)

Application Notes for anti-FXR1 antibody

Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 80kDa band observed in lysates of cell line NIH/3T3 (calculated MW of 59.9kDa according to NP_001013457.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Khandjian et al Hum Mol Genet.1998 Dec;7(13): 2121-8.; PMID: 9817930). Recommended concentration: 0.1-0.3ug/ml.

Other Notes

Small volumes of anti-FXR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FXR1. It may not necessarily be applicable to this product.

NCBI GI #

61835148

NCBI GeneID

8087

NCBI Accession #

NP_005078.2

NCBI Related Accession #

NP_001013456.1; NP_001013457.1

UniProt Secondary Accession #

Q7Z450; Q8N6R8; A8K9B8

UniProt Related Accession #

P51114

GenBank Nucleotide #

NM_005087.3

NCBI Official Full Name

fragile X mental retardation syndrome-related protein 1 isoform a

NCBI Official Synonym Full Names

FMR1 autosomal homolog 1

NCBI Official Symbol

FXR1

NCBI Official Synonym Symbols

FXR1P

UniProt Protein Name

Fragile X mental retardation syndrome-related protein 1

Protein Family

Fragile X mental retardation syndrome-related protein

UniProt Gene Name

FXR1

UniProt Synonym Gene Names

hFXR1p

UniProt Entry Name

FXR1_HUMAN

NCBI Protein Information

fragile X mental retardation syndrome-related protein 1

NCBI Summary for FXR1

The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for FXR1

FXR1: RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs. Interacts with FMR1 and FXR2. Interacts with TDRD3, and with CYFIP2 but not with CYFIP1. Expressed in all tissues examined including heart, brain, kidney and testis. Belongs to the FMR1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Translation; RNA-binding

Chromosomal Location of Human Ortholog: 3q28

Cellular Component: axon; costamere; cytoplasm; dendritic spine; membrane; nucleolus; perinuclear region of cytoplasm; polysome

Molecular Function: mRNA 3'-UTR binding; mRNA binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA binding; RNA strand annealing activity

Biological Process: apoptosis; cell differentiation; muscle development; negative regulation of translation

Research Articles on FXR1

1. FXR1P is a GSK3beta substrate with a role in regulating mood and emotion processing

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FXR1 antibody

Reference Product	PubMed Publications
FXR2 antibody	>40 publications with FXR1 and FXR2
EIF2C2 antibody	>6 publications with FXR1 and EIF2C2
DICER1 antibody	>3 publications with FXR1 and DICER1
TDRD3 antibody	>1 publications with FXR1 and TDRD3
CYFIP1 antibody	>1 publications with FXR1 and CYFIP1
CYFIP2 antibody	>1 publications with FXR1 and CYFIP2

Pathways associated with anti-FXR1 antibody

Products by Pathway	Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram

Diseases associated with anti-FXR1 antibody

Disease Name	Pubmed Publications
Necrosis Antibodies	>9 publications with FXR1 and Necrosis
Inflammation Antibodies	>6 publications with FXR1 and Inflammation
Adenocarcinoma Antibodies	>4 publications with FXR1 and Adenocarcinoma
Disease Models, Animal Antibodies	>4 publications with FXR1 and Disease Models, Animal
Lung Diseases Antibodies	>3 publications with FXR1 and Lung Diseases
Liver Diseases Antibodies	>3 publications with FXR1 and Liver Diseases
Lung Neoplasms Antibodies	>3 publications with FXR1 and Lung Neoplasms
Carcinoma, Hepatocellular Antibodies	>2 publications with FXR1 and Carcinoma, Hepatocellular
Heart Diseases Antibodies	>2 publications with FXR1 and Heart Diseases
Liver Neoplasms Antibodies	>2 publications with FXR1 and Liver Neoplasms

Organs/Tissues associated with anti-FXR1 antibody

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>29 publications with FXR1 and Nerve
Brain Antibodies	>29 publications with FXR1 and Brain
Muscle Antibodies	>23 publications with FXR1 and Muscle
Heart Antibodies	>11 publications with FXR1 and Heart
Liver Antibodies	>9 publications with FXR1 and Liver
Embryonic Tissue Antibodies	>9 publications with FXR1 and Embryonic Tissue
Blood Antibodies	>8 publications with FXR1 and Blood
Testis Antibodies	>7 publications with FXR1 and Testis
Lung Antibodies	>5 publications with FXR1 and Lung
Ovary Antibodies	>4 publications with FXR1 and Ovary