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Neurturin (NRTN) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420928

MBS420928 is an antibody targeting NRTN. Also known as Goat anti-Neurturin Antibody. Reactive in Tested: HumanExpected from sequence similarity: Human. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Neurturin (NRTN), Polyclonal Antibody
Full Product Name
Goat anti-Neurturin Antibody
Product Gene Name
anti-NRTN antibody
Product Synonym Names
NRTN; neurturin; NTN
Immunogen Sequence
DAHSRYHTVH ELSARE
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human
Expected from sequence similarity: Human
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Preparation and Storage
Aliquot and store at -20°C. Minimize freezing and thawing.
Antibody/Peptide Pairs
Neurturin peptide (MBS426583) is used for blocking the activity of Neurturin antibody (MBS420928)
OMIM
602018
Immunogen
Peptide with sequence C-DAHSRYHTVHELSARE, from the C Terminus of the protein sequence according to NP_004549.1.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-NRTN antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-NRTN antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 25kDa band observed in Human Heart and Mouse Heart lysates (calculated MW of 22.4kDa according to NP_004549.1).Recommended concentration: 0.1-0.3ug/ml.
IHC: Paraffin embedded Human Colon (Submucosal Plexus). Recommended concentration: 5ug/ml

Western Blot (WB) of anti-NRTN antibody

(0.1ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-NRTN Polyclonal Antibody – Cat# MBS420928

Immunohistochemistry (IHC) of anti-NRTN antibody

MBS420928 staining of paraffin embedded Human Colon. Steamed antigen retrieval with citrate buffer pH6, AP-staining.
Goat Anti-NRTN Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS420928

Other Notes

Small volumes of anti-NRTN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NRTN. It may not necessarily be applicable to this product.

NCBI GI #
4758826
NCBI GeneID
4902
NCBI Accession #
NP_004549.1
UniProt Secondary Accession #
B2RPE8
UniProt Related Accession #
Q99748
GenBank Nucleotide #
NM_004558.3
NCBI Official Full Name
neurturin preproprotein
NCBI Official Synonym Full Names
neurturin
NCBI Official Symbol
NRTN
NCBI Official Synonym Symbols
NTN
UniProt Protein Name
Neurturin
Protein Family
Neurturin
UniProt Gene Name
NRTN
UniProt Entry Name
NRTN_HUMAN
NCBI Protein Information
neurturin

NCBI Summary for NRTN

Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Jul 2008]

UniProt Comments for NRTN

NRTN: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Belongs to the TGF-beta family. GDNF subfamily.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: axon; extracellular region; intracellular

Molecular Function: growth factor activity; Ras guanyl-nucleotide exchange factor activity; receptor binding

Biological Process: MAPKKK cascade; nerve development; nervous system development; neural crest cell migration; neurite development; positive regulation of GTPase activity; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Hirschsprung Disease, Susceptibility To, 1
Show more

Research Articles on NRTN

1. In the cochlea, NTN immunostaining was found in the supporting cells of organ of Corti, including Deiters' cells, Hensen cells as well as Claudius' cells. In the spiral ganglia, NTN was seen in both the cell bodies and the nerve fibers of neurons.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NRTN antibody

 Reference Product  PubMed Publications
 GDNF antibody  >157 publications with NRTN and GDNF
 RET antibody  >114 publications with NRTN and RET
 GFRA2 antibody  >44 publications with NRTN and GFRA2
 GFRA1 antibody  >37 publications with NRTN and GFRA1
 ARTN antibody  >25 publications with NRTN and ARTN
 PSPN antibody  >14 publications with NRTN and PSPN
 NCAM1 antibody  >4 publications with NRTN and NCAM1
 TRPM8 antibody  >1 publications with NRTN and TRPM8

Pathways associated with anti-NRTN antibody

 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Of Activated FGFR1 Pathway antibodies  Downstream Signaling Of Activated FGFR1 Pathway Diagram
 Downstream Signaling Of Activated FGFR2 Pathway antibodies  Downstream Signaling Of Activated FGFR2 Pathway Diagram
 Downstream Signaling Of Activated FGFR3 Pathway antibodies  Downstream Signaling Of Activated FGFR3 Pathway Diagram

Diseases associated with anti-NRTN antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >35 publications with NRTN and Nervous System Diseases
 Nerve Degeneration Antibodies  >25 publications with NRTN and Nerve Degeneration
 Disease Models, Animal Antibodies  >24 publications with NRTN and Disease Models, Animal
 Congenital Abnormalities Antibodies  >8 publications with NRTN and Congenital Abnormalities
 Hirschsprung Disease Antibodies  >8 publications with NRTN and Hirschsprung Disease
 Inflammation Antibodies  >6 publications with NRTN and Inflammation
 Weight Loss Antibodies  >3 publications with NRTN and Weight Loss
 Hyperplasia Antibodies  >2 publications with NRTN and Hyperplasia
 Hypertrophy Antibodies  >2 publications with NRTN and Hypertrophy
 Necrosis Antibodies  >2 publications with NRTN and Necrosis

Organs/Tissues associated with anti-NRTN antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >71 publications with NRTN and Brain
 Eye Antibodies  >17 publications with NRTN and Eye
 Muscle Antibodies  >14 publications with NRTN and Muscle
 Intestine Antibodies  >14 publications with NRTN and Intestine
 Lung Antibodies  >3 publications with NRTN and Lung
 Pancreas Antibodies  >3 publications with NRTN and Pancreas
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