EP4 Prostaglandin Receptor (PTGER4) Antibody – Goat Polyclonal

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]

PTGER4: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: cell soma; integral to membrane; nuclear membrane; plasma membrane

Molecular Function: prostaglandin E receptor activity; protein binding

Biological Process: chemokinesis; female pregnancy; G-protein signaling, coupled to cAMP nucleotide second messenger; immune response; JNK cascade; maternal process involved in parturition; negative regulation of circadian sleep/wake cycle, REM sleep; negative regulation of cytokine secretion; negative regulation of inflammatory response; negative regulation of integrin activation; negative regulation of interleukin-1 alpha secretion; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of peptide secretion; positive regulation of bone resorption; positive regulation of cAMP biosynthetic process; positive regulation of cell adhesion; positive regulation of cell proliferation; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of cytokine secretion; positive regulation of inflammatory response; positive regulation of interleukin-8 production; positive regulation of osteoblast differentiation; positive regulation of smooth muscle cell migration; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of stress fiber formation; response to amino acid stimulus; response to drug; response to lipopolysaccharide; response to mechanical stimulus; response to progesterone stimulus; T-helper cell differentiation