BAG5 Antibody – Goat Polyclonal

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

BAG5: Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2. May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: cytosol; inclusion body; membrane; mitochondrion; nucleus; perinuclear region of cytoplasm

Molecular Function: adenyl-nucleotide exchange factor activity; chaperone binding; protein binding; protein kinase binding; ubiquitin protein ligase binding

Biological Process: Golgi organization and biogenesis; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein ubiquitination; negative regulation of ubiquitin-protein ligase activity; protein folding; regulation of ubiquitin-protein ligase activity