Goat Anti-SEC61A1 Polyclonal Antibody – Cat# MBS421035

(0.3ug/ml) staining of Human Brain (Cerebellum) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

SEC61A1 Antibody – Goat Polyclonal

Name: SEC61A1 Antibody; Polyclonal; Goat; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS421035
Price: 450 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421035

MBS421035 is an antibody targeting SEC61A1. Also known as Goat anti-SEC61A1 Antibody. Reactive in Tested: Human, Mouse; Expected from sequence similarity: Human, Dog, Cow, Pig. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SEC61A1, Polyclonal Antibody

Full Product Name

Goat anti-SEC61A1 Antibody

Product Gene Name

anti-SEC61A1 antibody

Product Synonym Names

SEC61A1; HSEC61; SEC61; SEC61A; protein transport protein SEC61 alpha subunit isoform 1; sec61 homolog; Sec61 alpha 1 subunit (S. cerevisiae); Sec61 alpha 1 subunit; Sec61 alpha-1; SEC61A1 antibody; HSEC61 antibody; SEC61 antibody; SEC61A antibody; protein transport protein SEC61 alpha subunit isoform 1 antibody; sec61 homolog antibody; Sec61 alpha 1 subunit (S. cerevisiae) antibody; Sec61 alpha 1 subunit antibody; Sec61 alpha-1 antibody

Immunogen Sequence

KEQSEVGSMG ALLF

Clonality

Polyclonal

Host

Goat

Species Reactivity

Tested: Human, Mouse; Expected from sequence similarity: Human, Dog, Cow, Pig

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Antibody/Peptide Pairs

SEC61A1 peptide (MBS425190) is used for blocking the activity of SEC61A1 antibody (MBS421035)

Molecular Weight

38,849 Da

OMIM

609213

Immunogen

Peptide with sequence C-KEQSEVGSMGALLF, from the C Terminus of the protein sequence according to NP_037468.1.

Epitope

C Terminus

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-SEC61A1 antibody

Peptide ELISA (EIA), Western Blot (WB)

Application Notes for anti-SEC61A1 antibody

Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx 48kDa band observed in Human Brain (Cerebelum) lysates (calculated MW of 52.3kDa according to NP_037468.1). Recommended concentration: 0.3-1ug/ml.

Other Notes

Small volumes of anti-SEC61A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SEC61A1. It may not necessarily be applicable to this product.

NCBI GI #

7019415

NCBI GeneID

29927

NCBI Accession #

NP_037468.1

UniProt Secondary Accession #

P38378; P57726; Q5JPF8; Q8N0Z4; Q8N3U3; Q8NC71; Q9BU16; Q9Y2R3

UniProt Related Accession #

P61619

GenBank Nucleotide #

NM_013336.3

NCBI Official Full Name

protein transport protein Sec61 subunit alpha isoform 1

NCBI Official Synonym Full Names

Sec61 translocon alpha 1 subunit

NCBI Official Symbol

SEC61A1

NCBI Official Synonym Symbols

SEC61; HSEC61; SEC61A

UniProt Protein Name

Protein transport protein Sec61 subunit alpha isoform 1

Protein Family

Protein transport protein

UniProt Gene Name

SEC61A1

UniProt Synonym Gene Names

SEC61A; Sec61 alpha-1

UniProt Entry Name

S61A1_HUMAN

NCBI Protein Information

protein transport protein Sec61 subunit alpha isoform 1

NCBI Summary for SEC61A1

The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]

UniProt Comments for SEC61A1

SEC61A1: Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane- bound ribosomes, either directly or through adapter proteins. Belongs to the SecY/SEC61-alpha family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: cytosol; integral to endoplasmic reticulum membrane; membrane; rough endoplasmic reticulum

Molecular Function: protein binding; ribosome binding

Biological Process: cell growth; endoplasmic reticulum organization and biogenesis; posttranslational protein targeting to membrane; protein targeting to ER; SRP-dependent cotranslational protein targeting to membrane

Research Articles on SEC61A1

1. Nuclear envelope associated endosome-mediated transfer depends on the nuclear envelope proteins SUN1 and SUN2, as well as the Sec61 translocon complex.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SEC61A1 antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Processing-Cross Presentation Pathway antibodies	Antigen Processing-Cross Presentation Pathway Diagram
Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies	Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
ER-Phagosome Pathway antibodies	ER-Phagosome Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
IRE1alpha Activates Chaperones Pathway antibodies	IRE1alpha Activates Chaperones Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Phagosome Pathway antibodies	Phagosome Pathway Diagram
Phagosome Pathway antibodies	Phagosome Pathway Diagram

Diseases associated with anti-SEC61A1 antibody

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>4 publications with SEC61A1 and Liver Diseases
Liver Neoplasms Antibodies	>3 publications with SEC61A1 and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>2 publications with SEC61A1 and Carcinoma, Hepatocellular
Fatty Liver Antibodies	>2 publications with SEC61A1 and Fatty Liver
Disease Models, Animal Antibodies	>1 publications with SEC61A1 and Disease Models, Animal
Fibrosis Antibodies	>1 publications with SEC61A1 and Fibrosis
Abnormalities, Drug-Induced Antibodies	>1 publications with SEC61A1 and Abnormalities, Drug-Induced
Necrosis Antibodies	>1 publications with SEC61A1 and Necrosis

Organs/Tissues associated with anti-SEC61A1 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>4 publications with SEC61A1 and Liver
Blood Antibodies	>3 publications with SEC61A1 and Blood
Nerve Antibodies	>2 publications with SEC61A1 and Nerve
Spleen Antibodies	>2 publications with SEC61A1 and Spleen
Pancreas Antibodies	>2 publications with SEC61A1 and Pancreas
Pituitary Gland Antibodies	>1 publications with SEC61A1 and Pituitary Gland
Bone Marrow Antibodies	>1 publications with SEC61A1 and Bone Marrow
Bone Antibodies	>1 publications with SEC61A1 and Bone
Kidney Antibodies	>1 publications with SEC61A1 and Kidney
Brain Antibodies	>1 publications with SEC61A1 and Brain