NFATC4 Antibody – Goat Polyclonal

This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

NFAT3: a transcription factor that plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Also control gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of lymphoid and nonlymphoid cells. Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. 23 alternatively spliced isoforms of the human protein hve been reported.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: cytoplasm; cytosol; intermediate filament cytoskeleton; nucleus; transcription factor complex

Molecular Function: peroxisome proliferator activated receptor binding; protein binding; transcription coactivator activity; transcription factor binding

Biological Process: calcineurin-NFAT signaling pathway; cellular respiration; DNA damage response, signal transduction resulting in induction of apoptosis; heart development; inflammatory response; muscle cell development; negative regulation of dendrite morphogenesis; negative regulation of protein binding; negative regulation of Wnt receptor signaling pathway; patterning of blood vessels; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; regulation of synaptic plasticity; smooth muscle cell differentiation; transcription from RNA polymerase II promoter