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GOT2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421070

MBS421070 is an antibody targeting GOT2. Also known as Goat anti-GOT2 (aa 295 to 306) Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Mouse, Rat. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
GOT2, Polyclonal Antibody
Full Product Name
Goat anti-GOT2 (aa 295 to 306) Antibody
Product Gene Name
anti-GOT2 antibody
Product Synonym Names
Goat Anti-GOT2 Antibody; GOT2; glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); FLJ40994; aspartate aminotransferase 2; GOT2 antibody; glutamic-oxaloacetic transaminase 2; mitochondrial (aspartate aminotransferase 2) antibody; FLJ40994 antibody; aspartate aminotransferase 2 antibody; GOT2 (aa 295 to 306)
Immunogen Sequence
CKDADEAKRV ES
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
GOT2 peptide (MBS426130) is used for blocking the activity of GOT2 antibody (MBS421070)
Molecular Weight
43,030 Da
OMIM
138150
Immunogen
Peptide with sequence CKDADEAKRVES, from the internal region of the protein sequence according to NP_002071.2.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-GOT2 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-GOT2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 45kDa band observed in Human Kidney and Liver lysates (calculated MW of 47.5kDa according to NP_002071.2). Recommended concentration: 0. 03-0.1ug/ml.

Western Blot (WB) of anti-GOT2 antibody

(0. 03ug/ml) staining of Human Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-GOT2 Polyclonal Antibody – Cat# MBS421070

Other Notes

Small volumes of anti-GOT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GOT2. It may not necessarily be applicable to this product.

NCBI GI #
73486658
NCBI GeneID
2806
NCBI Accession #
NP_002071.2
UniProt Secondary Accession #
Q53FL3; Q9BWA3; B4DJA6; E7ERW2
UniProt Related Accession #
P00505
GenBank Nucleotide #
NM_002080.3
NCBI Official Full Name
aspartate aminotransferase, mitochondrial isoform 1
NCBI Official Synonym Full Names
glutamic-oxaloacetic transaminase 2
NCBI Official Symbol
GOT2
NCBI Official Synonym Symbols
KAT4; KATIV; KYAT4; mitAAT
UniProt Protein Name
Aspartate aminotransferase, mitochondrial
UniProt Synonym Protein Names
Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A
UniProt Gene Name
GOT2
UniProt Synonym Gene Names
mAspAT; FABP-1; FABPpm
UniProt Entry Name
AATM_HUMAN
NCBI Protein Information
aspartate aminotransferase, mitochondrial

NCBI Summary for GOT2

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
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UniProt Comments for GOT2

GOT2: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Protein type: Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - arginine and proline; EC 2.6.1.7; Mitochondrial; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; EC 2.6.1.1; Transferase

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: cell surface; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; myelin sheath; perikaryon; plasma membrane; protein complex

Molecular Function: amino acid binding; aspartate transaminase activity; enzyme binding; identical protein binding; kynurenine-oxoglutarate transaminase activity; phospholipid binding; protein homodimerization activity; pyridoxal phosphate binding

Biological Process: 2-oxoglutarate metabolic process; 4-hydroxyproline catabolic process; amino acid biosynthetic process; aspartate biosynthetic process; aspartate catabolic process; aspartate metabolic process; fatty acid transport; gluconeogenesis; glutamate catabolic process to 2-oxoglutarate; glutamate catabolic process to aspartate; glutamate metabolic process; oxaloacetate metabolic process; response to ethanol
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Research Articles on GOT2

1. A previously unknown mechanism by which GOT2 acetylation stimulates the malate-aspartate NADH shuttle activity and oxidative protection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GOT2 antibody

 Reference Product  PubMed Publications
 MDH2 antibody  >5 publications with GOT2 and MDH2
 MDH1 antibody  >3 publications with GOT2 and MDH1
 TAT antibody  >2 publications with GOT2 and TAT

Pathways associated with anti-GOT2 antibody

 Products by Pathway  Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 4-hydroxyproline Degradation Pathway antibodies  4-hydroxyproline Degradation Pathway Diagram
 Alanine And Aspartate Metabolism Pathway antibodies  Alanine And Aspartate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies  Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine Biosynthesis Pathway antibodies  Arginine Biosynthesis Pathway Diagram

Diseases associated with anti-GOT2 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >4 publications with GOT2 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >4 publications with GOT2 and Cardiovascular Diseases
 Mental Disorders Antibodies  >2 publications with GOT2 and Mental Disorders
 Liver Diseases Antibodies  >2 publications with GOT2 and Liver Diseases
 Nervous System Diseases Antibodies  >2 publications with GOT2 and Nervous System Diseases
 Fatty Liver Antibodies  >2 publications with GOT2 and Fatty Liver
 Hypertension Antibodies  >2 publications with GOT2 and Hypertension
 Cardiomyopathies Antibodies  >1 publications with GOT2 and Cardiomyopathies
 Weight Loss Antibodies  >1 publications with GOT2 and Weight Loss
 Hypertrophy Antibodies  >1 publications with GOT2 and Hypertrophy

Organs/Tissues associated with anti-GOT2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with GOT2 and Blood
 Liver Antibodies  >6 publications with GOT2 and Liver
 Thyroid Antibodies  >3 publications with GOT2 and Thyroid
 Muscle Antibodies  >3 publications with GOT2 and Muscle
 Heart Antibodies  >3 publications with GOT2 and Heart
 Brain Antibodies  >3 publications with GOT2 and Brain
 Vascular Antibodies  >2 publications with GOT2 and Vascular
 Bladder Antibodies  >2 publications with GOT2 and Bladder
 Stomach Antibodies  >1 publications with GOT2 and Stomach
 Intestine Antibodies  >1 publications with GOT2 and Intestine
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