BCL2 Antibody – Goat Polyclonal

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Bcl-2: a antiapoptotic member of the Bcl-2 family. Regulates cell death by controlling the mitochondrial membrane permeability. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Phosphorylation by JNKs may increase its antiapoptotic functions.

Protein type: Autophagy; Apoptosis; Oncoprotein; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q21.3

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrial outer membrane; mitochondrion; myelin sheath; nuclear membrane; nucleus; pore complex

Molecular Function: BH3 domain binding; channel activity; channel inhibitor activity; identical protein binding; protease binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein phosphatase 2A binding; sequence-specific DNA binding; transcription factor binding; ubiquitin protein ligase binding

Biological Process: actin filament organization; apoptosis; axon regeneration; axonogenesis; B cell homeostasis; B cell lineage commitment; B cell proliferation; B cell receptor signaling pathway; behavioral fear response; CD8-positive, alpha-beta T cell lineage commitment; cell aging; cell growth; cellular response to glucose starvation; cochlear nucleus development; defense response to virus; digestive tract morphogenesis; DNA damage response, signal transduction resulting in induction of apoptosis; ear development; endoplasmic reticulum calcium ion homeostasis; female pregnancy; focal adhesion formation; gland morphogenesis; glomerulus development; hair follicle morphogenesis; homeostasis of number of cells within a tissue; humoral immune response; induction of apoptosis by oxidative stress; induction of apoptosis via death domain receptors; lymphoid progenitor cell differentiation; male gonad development; melanin metabolic process; melanocyte differentiation; mesenchymal cell development; metanephros development; negative regulation of apoptosis; negative regulation of autophagy; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cellular pH reduction; negative regulation of mitochondrial depolarization; negative regulation of myeloid cell apoptosis; negative regulation of neuron apoptosis; negative regulation of ossification; negative regulation of osteoblast proliferation; negative regulation of retinal cell programmed cell death; neuron apoptosis; oocyte development; organ growth; ossification; ovarian follicle development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pigment granule organization and biogenesis; positive regulation of B cell proliferation; positive regulation of catalytic activity; positive regulation of cell growth; positive regulation of melanocyte differentiation; positive regulation of multicellular organism growth; positive regulation of neuron maturation; positive regulation of peptidyl-serine phosphorylation; positive regulation of skeletal muscle fiber development; positive regulation of smooth muscle cell migration; post-embryonic development; protein amino acid dephosphorylation; protein polyubiquitination; regulation of calcium ion transport; regulation of cell-matrix adhesion; regulation of gene expression; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; regulation of nitrogen utilization; regulation of protein heterodimerization activity; regulation of protein homodimerization activity; regulation of protein stability; regulation of transmembrane transporter activity; regulation of viral genome replication; release of cytochrome c from mitochondria; renal system process; response to cytokine stimulus; response to DNA damage stimulus; response to drug; response to gamma radiation; response to glucocorticoid stimulus; response to hydrogen peroxide; response to iron ion; response to nicotine; response to radiation; response to toxin; response to UV-B; spleen development; T cell differentiation in the thymus; T cell homeostasis; thymus development; transmembrane transport; ureteric bud branching