IDE Antibody – Goat Polyclonal

IDE: Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. Belongs to the peptidase M16 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.56; Protease; Nuclear receptor co-regulator; Cell surface

Cellular Component: cell surface; cytoplasm; cytosol; extracellular region; extracellular space; membrane; mitochondrion; nucleoplasm; nucleus; peroxisomal matrix; peroxisome; plasma membrane

Molecular Function: ATP binding; ATPase activity; beta-amyloid binding; beta-endorphin binding; catalytic activity; glycoprotein binding; hydrolase activity; insulin binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; nucleotide binding; peptidase activity; peptide binding; peptide hormone binding; protein homodimerization activity; receptor binding; ubiquitin binding; zinc ion binding

Biological Process: beta-amyloid metabolic process; cellular protein catabolic process; determination of adult life span; hormone catabolic process; metabolic process; negative regulation of proteolysis; peptide catabolic process; positive regulation of protein oligomerization; protein heterooligomerization; protein homooligomerization; protein homotetramerization; protein processing; proteolysis; proteolysis involved in cellular protein catabolic process