ZNF703 Antibody – Goat Polyclonal

ZNF703: Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. Luminal B breast cancers are the clinically more aggressive estrogen receptor-positive tumors. Amplification of a distal 8p12 locus occurs in around one third of the cases and ZNF703 is the single gene within the minimal amplicon. Amplification of the gene correlates with its protein expression in tumor cells. ZNF703 is a classical breast cancer oncogene since it is able to transform non-malignant cells and increase cellular proliferation. Belongs to the Elbow/Noc family.

Protein type: C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 8p11.23

Cellular Component: cytoplasm; nuclear matrix; nucleus; protein complex

Molecular Function: metal ion binding; nucleic acid binding; protein binding

Biological Process: negative regulation of homotypic cell-cell adhesion; negative regulation of transcription, DNA-dependent; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of mammary gland epithelial cell proliferation; regulation of cell cycle; regulation of transcription, DNA-dependent; regulation of transforming growth factor beta receptor signaling pathway; transcription, DNA-dependent