Goat Anti-RASAL1 Polyclonal Antibody – Cat# MBS421130

(0.3ug/ml) staining of Human Thyroid lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

RASAL1 Antibody – Goat Polyclonal

Name: RASAL1 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS421130
Price: 450 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421130

MBS421130 is an antibody targeting RASAL1. Also known as Goat anti-RASAL Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RASAL (RASAL1), Polyclonal Antibody

Full Product Name

Goat anti-RASAL Antibody

Product Gene Name

anti-RASAL1 antibody

Product Synonym Gene Name

RASAL

Product Synonym Names

RASAL1; RASAL; RAS protein activator like 1 (GAP1 like); GAP1 like protein; RAS-GTPase-activating protein-like; RAS protein activator like 1; RASAL1 antibody; RASAL antibody; RAS protein activator like 1 (GAP1 like) antibody; GAP1 like protein antibody; RAS-GTPase-activating protein-like antibody; RAS protein activator like 1 antibody

Immunogen Sequence

QERGKAALGP LGP

Clonality

Polyclonal

Host

Goat

Species Reactivity

Tested: Human; Expected from sequence similarity: Human

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Antibody/Peptide Pairs

RASAL peptide (MBS425645) is used for blocking the activity of RASAL antibody (MBS421130)

Molecular Weight

90,145 Da

OMIM

604118

Immunogen

Peptide with sequence C-QERGKAALGPLGP, from the C Terminus of the protein sequence according to NP_004649.1.

Epitope

C Terminus

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-RASAL1 antibody

Peptide ELISA (EIA), Western Blot (WB)

Application Notes for anti-RASAL1 antibody

Peptide ELISA: Antibody detection limit dilution 1: 32000.

Other Notes

Small volumes of anti-RASAL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RASAL1. It may not necessarily be applicable to this product.

NCBI GI #

4759026

NCBI GeneID

8437

NCBI Accession #

NP_004649.1

UniProt Secondary Accession #

Q52M03; Q59H24; Q96CC7; B7ZKM4; C9JFK5; F8VQX1

UniProt Related Accession #

O95294

GenBank Nucleotide #

NM_004658.1

NCBI Official Full Name

rasGAP-activating-like protein 1

NCBI Official Synonym Full Names

RAS protein activator like 1

NCBI Official Symbol

RASAL1

NCBI Official Synonym Symbols

RASAL

UniProt Protein Name

RasGAP-activating-like protein 1

UniProt Synonym Protein Names

RAS protein activator like 1

Protein Family

RasGAP-activating-like protein

UniProt Gene Name

RASAL1

UniProt Entry Name

RASL1_HUMAN

NCBI Protein Information

rasGAP-activating-like protein 1

NCBI Summary for RASAL1

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]

UniProt Comments for RASAL1

RASAL1: a GTPase activating protein for Ras. Negatively regulates Ras (H-Ras) signaling activity. Two alternatively-spliced isoforms have been described. PITX1 inhibits tumorigenicity of the Ras pathway by inducing the transcription of RASAL1, which in turn inactivates Ras. Two alternatively-spliced isoforms have been described.

Protein type: GAPs, Ras; GAPs

Chromosomal Location of Human Ortholog: 12q23-q24

Cellular Component: cytosol; plasma membrane

Molecular Function: GTPase activator activity; metal ion binding; phospholipid binding

Biological Process: MAPKKK cascade; negative regulation of Ras protein signal transduction; positive regulation of GTPase activity; signal transduction

Research Articles on RASAL1

1. These findings suggest that Ebp1 suppressed thyroid cancer cell lines by upregulating RASRAL expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-RASAL1 antibody

Products by Pathway	Pathway Diagram
ARMS-mediated Activation Pathway antibodies	ARMS-mediated Activation Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Downstream Signal Transduction Pathway antibodies	Downstream Signal Transduction Pathway Diagram
Downstream Signaling Of Activated FGFR1 Pathway antibodies	Downstream Signaling Of Activated FGFR1 Pathway Diagram
Downstream Signaling Of Activated FGFR2 Pathway antibodies	Downstream Signaling Of Activated FGFR2 Pathway Diagram
Downstream Signaling Of Activated FGFR3 Pathway antibodies	Downstream Signaling Of Activated FGFR3 Pathway Diagram

Diseases associated with anti-RASAL1 antibody

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>9 publications with RASAL1 and Adenocarcinoma
Kidney Diseases Antibodies	>3 publications with RASAL1 and Kidney Diseases
Carcinoma, Hepatocellular Antibodies	>2 publications with RASAL1 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>2 publications with RASAL1 and Liver Neoplasms
Neoplasm Metastasis Antibodies	>2 publications with RASAL1 and Neoplasm Metastasis
Disease Models, Animal Antibodies	>2 publications with RASAL1 and Disease Models, Animal
Neoplasms, Experimental Antibodies	>1 publications with RASAL1 and Neoplasms, Experimental
Inflammation Antibodies	>1 publications with RASAL1 and Inflammation
Necrosis Antibodies	>1 publications with RASAL1 and Necrosis

Organs/Tissues associated with anti-RASAL1 antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>5 publications with RASAL1 and Kidney
Lymph Node Antibodies	>2 publications with RASAL1 and Lymph Node
Eye Antibodies	>2 publications with RASAL1 and Eye
Blood Antibodies	>2 publications with RASAL1 and Blood
Lymph Antibodies	>2 publications with RASAL1 and Lymph
Brain Antibodies	>1 publications with RASAL1 and Brain