GLUT8/SLC2A8 (SLC2A8) Antibody – Goat Polyclonal

This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

SLC2A8: Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family

Chromosomal Location of Human Ortholog: 9q33.3

Cellular Component: cytoplasmic vesicle membrane; integral to plasma membrane; lysosomal membrane; plasma membrane; synaptic vesicle

Molecular Function: D-glucose transmembrane transporter activity; glucose binding; glucose transmembrane transporter activity; sugar:hydrogen ion symporter activity

Biological Process: carbohydrate metabolic process; glucose import; glucose transport; insulin receptor signaling pathway; male meiosis I; proton transport; response to hypoxia