RGS14 Antibody – Goat Polyclonal

This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

RGS14: Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not G(o) alpha subunit GNAO1 and G(i) alpha subunit GNAI2. Confers GAP activity on G(o) alpha subunit GNAI0 and G(i) alpha subunits GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS1 and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Probably required for the nerve growth factor (NGF)-mediated neurite outgrowth. May be involved in visual memory processing capacity and hippocampal-based learning and memory. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, RGS

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: cell junction; centrosome; cytoplasm; dendrite; dendritic spine; microtubule; nuclear body; nucleus; plasma membrane; PML body; postsynaptic density; postsynaptic membrane; spindle; spindle pole

Molecular Function: G-protein alpha-subunit binding; GDP-dissociation inhibitor activity; GTPase activating protein binding; GTPase activator activity; microtubule binding; protein binding; protein kinase binding; receptor signaling complex scaffold activity; receptor signaling protein activity

Biological Process: cell division; chromosome segregation; learning; long-term memory; mitosis; negative regulation of MAP kinase activity; negative regulation of synaptic plasticity; nucleocytoplasmic transport; platelet-derived growth factor receptor signaling pathway; positive regulation of GTPase activity; positive regulation of neurogenesis; regulation of G-protein coupled receptor protein signaling pathway; regulation of transcription in response to stress; response to oxidative stress; spindle organization and biogenesis; visual learning; zygote asymmetric cell division