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VMAT2/SLC18A2 (SLC18A2) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421308

MBS421308 is an antibody targeting SLC18A2. Also known as Goat anti-VMAT2/SLC18A2 Antibody. Reactive in Tested: Human, MouseExpected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
VMAT2/SLC18A2, Polyclonal Antibody
Full Product Name
Goat anti-VMAT2/SLC18A2 Antibody
Product Gene Name
anti-SLC18A2 antibody
Product Synonym Gene Name
VMAT2
Product Synonym Names
SLC18A2; VMAT2; SVAT; SVMT; VAT2; solute carrier family 18 (vesicular monoamine), member 2; MGC120477; MGC120478; MGC26538; VMAT2 antibody; SLC18A2 antibody; SVAT antibody; SVMT antibody; VAT2 antibody; solute carrier family 18 (vesicular monoamine); member 2 antibody; VMAT2 / SLC18A2
Immunogen Sequence
SYPIGEDEES ESD
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human, Mouse
Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
VMAT2 / SLC18A2 peptide (MBS425488) is used for blocking the activity of VMAT2/SLC18A2 antibody (MBS421308)
OMIM
193001
Immunogen
Peptide with sequence C-SYPIGEDEESESD, from the C Terminus of the protein sequence according to NP_003045.2.
Epitope
C Terminus
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-SLC18A2 antibody
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SLC18A2 antibody
ELISA: antibody detection limit dilution 1:128000.
Western blot: Approx 55-58kDa band observed in Human Adrenal Gland and approx. 50kDa in Mouse Brain lysates (calculated MW of 55.7kDa according to Human NP_003045.2 and Mouse NP_766111.1). Recommended concentration 1-3ug/ml. Primary incubation 1 hour at room temperature.

Western Blot (WB) of anti-SLC18A2 antibody

(1ug/ml) staining of Human Placenta (A), Human Uterus (B), Human Adrenal Gland (C) and Human Pancreas (D) lysates (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-SLC18A2 Polyclonal Antibody – Cat# MBS421308

Immunohistochemistry (IHC) of anti-SLC18A2 antibody

MBS421308 (5ug/ml) staining of paraffin embedded Human Pancreas. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. This data is from a previous batch, not on sale.
Goat Anti-SLC18A2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS421308

Immunohistochemistry (IHC) of anti-SLC18A2 antibody

MBS421308 (2.5ug/ml) staining of paraffin embedded Human Adrenal Gland. Heat induced antigen retrieval with citrate buffer pH 6, HRP-staining.This data is from a previous batch, not on sale.
Goat Anti-SLC18A2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS421308

Immunohistochemistry (IHC) of anti-SLC18A2 antibody

MBS421308 Negative Control showing staining of paraffin embedded Human Adrenal Gland, with no primary antibody. This data is from a previous batch, not on sale.
Goat Anti-SLC18A2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS421308

Other Notes

Small volumes of anti-SLC18A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC18A2. It may not necessarily be applicable to this product.

NCBI GI #
42476325
NCBI GeneID
6571
NCBI Accession #
NP_003045.2
UniProt Secondary Accession #
Q15876; Q4G147; Q5VW49; Q9H3P6; B2RC96; D3DRC4
UniProt Related Accession #
Q05940
GenBank Nucleotide #
NM_003054.4
NCBI Official Full Name
synaptic vesicular amine transporter
NCBI Official Synonym Full Names
solute carrier family 18 member A2
NCBI Official Symbol
SLC18A2
NCBI Official Synonym Symbols
SVAT; SVMT; VAT2; VMAT2
UniProt Protein Name
Synaptic vesicular amine transporter
UniProt Synonym Protein Names
Monoamine transporter; Solute carrier family 18 member 2; Vesicular amine transporter 2; VAT2
Protein Family
Synaptic vesicular amine transporter
UniProt Gene Name
SLC18A2
UniProt Synonym Gene Names
SVMT; VMAT2; VAT2
UniProt Entry Name
VMAT2_HUMAN
NCBI Protein Information
synaptic vesicular amine transporter

NCBI Summary for SLC18A2

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011]
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UniProt Comments for SLC18A2

SLC18A2: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis. Belongs to the major facilitator superfamily. Vesicular transporter family.

Protein type: Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 10q25

Cellular Component: cell soma; integral to plasma membrane; membrane; plasma membrane; synaptic vesicle; synaptic vesicle membrane; terminal button

Molecular Function: amine transmembrane transporter activity; drug binding; enzyme binding; heat shock protein binding; monoamine transmembrane transporter activity; serotonin transmembrane transporter activity

Biological Process: aging; dopamine transport; endocytic recycling; glucose homeostasis; insulin secretion; locomotory behavior; monoamine transport; negative regulation of neurotransmitter transport; neurotransmitter secretion; post-embryonic development; response to amphetamine; response to cocaine; response to corticosterone stimulus; response to herbicide; response to starvation; response to zinc ion; sequestering of neurotransmitter; serotonin transport; synaptic transmission; synaptic vesicle amine transport; transmembrane transport
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Research Articles on SLC18A2

1. Two SNPs (rs10082463 & rs363285) of SLC18A2 were nominally associated with cognition.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC18A2 antibody

 Reference Product  PubMed Publications
 SLC6A3 antibody  >148 publications with SLC18A2 and SLC6A3
 SNAP25 antibody  >3 publications with SLC18A2 and SNAP25
 CPLX1 antibody  >1 publications with SLC18A2 and CPLX1
 SLC22A2 antibody  >1 publications with SLC18A2 and SLC22A2

Pathways associated with anti-SLC18A2 antibody

 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Dopamine Neurotransmitter Release Cycle Pathway antibodies  Dopamine Neurotransmitter Release Cycle Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Na+/Cl- Dependent Neurotransmitter Transporters Pathway antibodies  Na+/Cl- Dependent Neurotransmitter Transporters Pathway Diagram

Diseases associated with anti-SLC18A2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >137 publications with SLC18A2 and Nervous System Diseases
 Brain Diseases Antibodies  >114 publications with SLC18A2 and Brain Diseases
 Movement Disorders Antibodies  >109 publications with SLC18A2 and Movement Disorders
 Parkinsonian Disorders Antibodies  >90 publications with SLC18A2 and Parkinsonian Disorders
 Parkinson Disease Antibodies  >65 publications with SLC18A2 and Parkinson Disease
 Disease Models, Animal Antibodies  >62 publications with SLC18A2 and Disease Models, Animal
 Poisoning Antibodies  >23 publications with SLC18A2 and Poisoning
 Neurotoxicity Syndromes Antibodies  >23 publications with SLC18A2 and Neurotoxicity Syndromes
 Nerve Degeneration Antibodies  >22 publications with SLC18A2 and Nerve Degeneration
 Parkinson Disease, Secondary Antibodies  >17 publications with SLC18A2 and Parkinson Disease, Secondary

Organs/Tissues associated with anti-SLC18A2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >320 publications with SLC18A2 and Brain
 Blood Antibodies  >54 publications with SLC18A2 and Blood
 Pancreas Antibodies  >21 publications with SLC18A2 and Pancreas
 Stomach Antibodies  >18 publications with SLC18A2 and Stomach
 Adrenal Gland Antibodies  >12 publications with SLC18A2 and Adrenal Gland
 Embryonic Tissue Antibodies  >8 publications with SLC18A2 and Embryonic Tissue
 Eye Antibodies  >8 publications with SLC18A2 and Eye
 Skin Antibodies  >5 publications with SLC18A2 and Skin
 Muscle Antibodies  >5 publications with SLC18A2 and Muscle
 Kidney Antibodies  >5 publications with SLC18A2 and Kidney
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