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CCKA Receptor (CCKAR) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421309

MBS421309 is an antibody targeting Cckar. Also known as Goat anti-CCKA Receptor (mouse) Antibody. Reactive in Tested: Rat; Expected from sequence similarity: Mouse, Rat, Rabbit. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CCKA Receptor (Cckar), Polyclonal Antibody
Full Product Name
Goat anti-CCKA Receptor (mouse) Antibody
Product Gene Name
anti-Cckar antibody
Product Synonym Gene Name
CCKA
Product Synonym Names
Cckar; cholecystokinin A receptor; AW106902; Cckar antibody; cholecystokinin A receptor antibody; AW106902 antibody; CCKA Receptor (mouse)
Immunogen Sequence
KFDASQKKSA KEKR
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Rat; Expected from sequence similarity: Mouse, Rat, Rabbit
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
CCKA Receptor peptide (MBS425052) is used for blocking the activity of CCKA Receptor antibody (MBS421309)
Molecular Weight
48,437 Da
Immunogen
Peptide with sequence C-KFDASQKKSAKEKR, from the internal region of the protein sequence according to NP_033957.1.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-Cckar antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-Cckar antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx.75kDa band observed in purified membranes of Rat insulinoma cell line RIN14B (calculated MW of 48.4kDa according to NP_033957.1). Data were published by El-Kouhen K and Morisset J. Int J Endocrinol.2009;2009: 875167; PMID: 20011057. The observed molecular weight also corresponds to earlier findings in literature with different antibodies (Morisset et al J Histochem Cytochem.2003 Nov;51(11): 1501-13; PMID: 14566022). Recommended concentration: 0.1-0.3ug/ml.

Other Notes

Small volumes of anti-Cckar antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Cckar. It may not necessarily be applicable to this product.

NCBI GI #
6753306
NCBI GeneID
12425
NCBI Accession #
NP_033957.1
UniProt Secondary Accession #
Q8VCC7; Q9DBV6
UniProt Related Accession #
O08786
GenBank Nucleotide #
NM_009827.2
NCBI Official Full Name
cholecystokinin receptor type A
NCBI Official Synonym Full Names
cholecystokinin A receptor
NCBI Official Symbol
Cckar
NCBI Official Synonym Symbols
AW106902
UniProt Protein Name
Cholecystokinin receptor type A
UniProt Synonym Protein Names
Cholecystokinin-1 receptor; CCK1-R
Protein Family
Cholecystokinin receptor
UniProt Gene Name
Cckar
UniProt Synonym Gene Names
CCK-A receptor; CCK-AR; CCK1-R
UniProt Entry Name
CCKAR_MOUSE
NCBI Protein Information
cholecystokinin receptor type A

UniProt Comments for Cckar

CCKAR: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endosome; integral to membrane; lysosome; membrane; plasma membrane; terminal button

Molecular Function: cholecystokinin receptor activity; G-protein coupled receptor activity; signal transducer activity

Biological Process: actin cytoskeleton reorganization; axonogenesis; digestion; eating behavior; elevation of cytosolic calcium ion concentration; feeding behavior; forebrain development; G-protein coupled receptor protein signaling pathway; gastric acid secretion; insulin secretion; neuron migration; pancreatic juice secretion; reduction of food intake in response to dietary excess; regulation of calcium ion transport; regulation of hormone secretion; regulation of potassium ion transport; response to heat; response to starvation; signal transduction; thermoregulation
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Research Articles on Cckar

1. There is functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Cckar antibody

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Insulin Secretion Pathway antibodies  Insulin Secretion Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-Cckar antibody

 Disease Name  Pubmed Publications
 Obesity Antibodies  >11 publications with Cckar and Obesity
 Diabetes Mellitus Antibodies  >6 publications with Cckar and Diabetes Mellitus
 Disease Models, Animal Antibodies  >4 publications with Cckar and Disease Models, Animal
 Weight Gain Antibodies  >4 publications with Cckar and Weight Gain
 Kidney Diseases Antibodies  >3 publications with Cckar and Kidney Diseases
 Hyperglycemia Antibodies  >3 publications with Cckar and Hyperglycemia
 Neurobehavioral Manifestations Antibodies  >3 publications with Cckar and Neurobehavioral Manifestations
 Gallbladder Neoplasms Antibodies  >3 publications with Cckar and Gallbladder Neoplasms
 Weight Loss Antibodies  >2 publications with Cckar and Weight Loss
 Inflammation Antibodies  >2 publications with Cckar and Inflammation

Organs/Tissues associated with anti-Cckar antibody

 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >13 publications with Cckar and Pancreas
 Stomach Antibodies  >11 publications with Cckar and Stomach
 Kidney Antibodies  >6 publications with Cckar and Kidney
 Heart Antibodies  >2 publications with Cckar and Heart
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